Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines. |
Domain |
PF00801 PKD domain |
Function |
Could be a melanogenic enzyme. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001818 negative regulation of cytokine production GO:0030282 bone mineralization GO:0031214 biomineral tissue development GO:0032640 tumor necrosis factor production GO:0032680 regulation of tumor necrosis factor production GO:0032720 negative regulation of tumor necrosis factor production GO:0071706 tumor necrosis factor superfamily cytokine production GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production |
Molecular Function |
GO:0005178 integrin binding GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0050839 cell adhesion molecule binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0042470 melanosome GO:0048770 pigment granule |
KEGG | - |
Reactome |
R-HSA-8857538: PTK6 promotes HIF1A stabilization R-HSA-162582: Signal Transduction R-HSA-8848021: Signaling by PTK6 |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPNMB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GPNMB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPNMB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPNMB in various data sets.
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Points in the above scatter plot represent the mutation difference of GPNMB in various data sets.
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Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPNMB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPNMB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPNMB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPNMB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPNMB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPNMB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GPNMB |
Name | glycoprotein (transmembrane) nmb |
Aliases | HGFIN; glycoprotein NMB; glycoprotein nmb-like protein; osteoactivin; transmembrane glycoprotein HGFIN; Tran ...... |
Chromosomal Location | 7p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPNMB collected from DrugBank database. |
Details on drugs targeting GPNMB.
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