Summary | |
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Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00003 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 Receptor family ligand binding region PF07562 Nine Cysteines Domain of family 3 GPCR |
Function |
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids. |
Biological Process |
GO:0001101 response to acid chemical GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0043200 response to amino acid |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04621 NOD-like receptor signaling pathway |
Reactome |
R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPRC6A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPRC6A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPRC6A in various data sets.
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Points in the above scatter plot represent the mutation difference of GPRC6A in various data sets.
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Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPRC6A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPRC6A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPRC6A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPRC6A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPRC6A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPRC6A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GPRC6A |
Name | G protein-coupled receptor, class C, group 6, member A |
Aliases | bA86F4.3; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; predic ...... |
Chromosomal Location | 6q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPRC6A collected from DrugBank database. |
There is no record. |