Summary | |
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Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF02188 GoLoco motif |
Function |
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002532 production of molecular mediator involved in inflammatory response GO:0002534 cytokine production involved in inflammatory response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0040017 positive regulation of locomotion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0060326 cell chemotaxis GO:1900015 regulation of cytokine production involved in inflammatory response GO:1900017 positive regulation of cytokine production involved in inflammatory response GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPSM3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPSM3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPSM3 in various data sets.
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Points in the above scatter plot represent the mutation difference of GPSM3 in various data sets.
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Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPSM3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPSM3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPSM3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPSM3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPSM3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPSM3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GPSM3 |
Name | G-protein signaling modulator 3 |
Aliases | NG1; G18.1a; G18.1b; G18.2; activator of G-protein signaling 4; C6orf9; chromosome 6 open reading frame 9; G ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPSM3 collected from DrugBank database. |
There is no record. |