Browse GPX1

Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF00255 Glutathione peroxidase
Function

Protects the hemoglobin in erythrocytes from oxidative breakdown.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001525 angiogenesis
GO:0001659 temperature homeostasis
GO:0001667 ameboidal-type cell migration
GO:0001836 release of cytochrome c from mitochondria
GO:0001885 endothelial cell development
GO:0002064 epithelial cell development
GO:0002437 inflammatory response to antigenic stimulus
GO:0002683 negative regulation of immune system process
GO:0002861 regulation of inflammatory response to antigenic stimulus
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003018 vascular process in circulatory system
GO:0003158 endothelium development
GO:0006195 purine nucleotide catabolic process
GO:0006575 cellular modified amino acid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006690 icosanoid metabolic process
GO:0006749 glutathione metabolic process
GO:0006790 sulfur compound metabolic process
GO:0006979 response to oxidative stress
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007605 sensory perception of sound
GO:0008015 blood circulation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009166 nucleotide catabolic process
GO:0009314 response to radiation
GO:0009410 response to xenobiotic stimulus
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009608 response to symbiont
GO:0009609 response to symbiotic bacterium
GO:0009636 response to toxic substance
GO:0009650 UV protection
GO:0009894 regulation of catabolic process
GO:0010035 response to inorganic substance
GO:0010212 response to ionizing radiation
GO:0010269 response to selenium ion
GO:0010332 response to gamma radiation
GO:0010466 negative regulation of peptidase activity
GO:0010498 proteasomal protein catabolic process
GO:0010631 epithelial cell migration
GO:0010639 negative regulation of organelle organization
GO:0010821 regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0010951 negative regulation of endopeptidase activity
GO:0014706 striated muscle tissue development
GO:0014902 myotube differentiation
GO:0014904 myotube cell development
GO:0018158 protein oxidation
GO:0019372 lipoxygenase pathway
GO:0019439 aromatic compound catabolic process
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0031099 regeneration
GO:0031329 regulation of cellular catabolic process
GO:0031348 negative regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0033194 response to hydroperoxide
GO:0033598 mammary gland epithelial cell proliferation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0034599 cellular response to oxidative stress
GO:0034655 nucleobase-containing compound catabolic process
GO:0035150 regulation of tube size
GO:0036473 cell death in response to oxidative stress
GO:0040029 regulation of gene expression, epigenetic
GO:0042176 regulation of protein catabolic process
GO:0042246 tissue regeneration
GO:0042311 vasodilation
GO:0042542 response to hydrogen peroxide
GO:0042692 muscle cell differentiation
GO:0042743 hydrogen peroxide metabolic process
GO:0042744 hydrogen peroxide catabolic process
GO:0043062 extracellular structure organization
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403 skeletal muscle tissue regeneration
GO:0043491 protein kinase B signaling
GO:0043523 regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0044270 cellular nitrogen compound catabolic process
GO:0045444 fat cell differentiation
GO:0045446 endothelial cell differentiation
GO:0045454 cell redox homeostasis
GO:0045861 negative regulation of proteolysis
GO:0046434 organophosphate catabolic process
GO:0046486 glycerolipid metabolic process
GO:0046700 heterocycle catabolic process
GO:0048514 blood vessel morphogenesis
GO:0048732 gland development
GO:0048741 skeletal muscle fiber development
GO:0048747 muscle fiber development
GO:0048871 multicellular organismal homeostasis
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050880 regulation of blood vessel size
GO:0050954 sensory perception of mechanical stimulus
GO:0051146 striated muscle cell differentiation
GO:0051346 negative regulation of hydrolase activity
GO:0051402 neuron apoptotic process
GO:0051450 myoblast proliferation
GO:0051702 interaction with symbiont
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0060047 heart contraction
GO:0060055 angiogenesis involved in wound healing
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061180 mammary gland epithelium development
GO:0070997 neuron death
GO:0072523 purine-containing compound catabolic process
GO:0072593 reactive oxygen species metabolic process
GO:0090066 regulation of anatomical structure size
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090199 regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097435 fibril organization
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901214 regulation of neuron death
GO:1901292 nucleoside phosphate catabolic process
GO:1901361 organic cyclic compound catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1902903 regulation of fibril organization
GO:1902905 positive regulation of fibril organization
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903362 regulation of cellular protein catabolic process
GO:1990748 cellular detoxification
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0017124 SH3 domain binding
Cellular Component GO:0005759 mitochondrial matrix
GO:0016234 inclusion body
GO:0097413 Lewy body
> KEGG and Reactome Pathway
 
KEGG hsa04918 Thyroid hormone synthesis
hsa00480 Glutathione metabolism
hsa00590 Arachidonic acid metabolism
Reactome R-HSA-2142753: Arachidonic acid metabolism
R-HSA-2262752: Cellular responses to stress
R-HSA-3299685: Detoxification of Reactive Oxygen Species
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-15869: Metabolism of nucleotides
R-HSA-74259: Purine catabolism
R-HSA-73847: Purine metabolism
R-HSA-2142712: Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770: Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-2142688: Synthesis of 5-eicosatetraenoic acids
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GPX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GPX1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -1.74; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GPX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.050.882
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1020.981
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0070.998
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4140.394
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3670.88
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4740.879
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3340.505
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4910.801
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2880.902
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0970.97
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3710.928
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1360.139
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GPX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 014014.3-14.31
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPX1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GPX1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GPX1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGPX1
Nameglutathione peroxidase 1
Aliases GPXD; GSHPX1; GPx-1; GSHPx-1; cellular glutathione peroxidase
Chromosomal Location3p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GPX1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GPX1.
ID Name Drug Type Targets #Targets
DB00143GlutathioneSmall MoleculeAKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......41