Summary | |
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Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane |
Domain |
PF02181 Formin Homology 2 Domain PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. |
Biological Process |
GO:0048167 regulation of synaptic plasticity GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0060292 long term synaptic depression |
Molecular Function | - |
Cellular Component |
GO:0030425 dendrite GO:0043197 dendritic spine GO:0044309 neuron spine GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GRID2IP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GRID2IP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GRID2IP in various data sets.
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Points in the above scatter plot represent the mutation difference of GRID2IP in various data sets.
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Summary | |
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Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRID2IP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRID2IP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRID2IP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRID2IP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GRID2IP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GRID2IP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GRID2IP |
Name | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein |
Aliases | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; DELPHILIN; glutamate receptor, ionotr ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GRID2IP collected from DrugBank database. |
There is no record. |