TISIDB

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Multi-pass membrane protein Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein
Domain	PF01094 Receptor family ligand binding region PF00060 Ligand-gated ion channel PF10613 Ligated ion channel L-glutamate- and glycine-binding site PF10565 N-methyl D-aspartate receptor 2B3 C-terminus
Function	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0007215 glutamate receptor signaling pathway GO:0007611 learning or memory GO:0035235 ionotropic glutamate receptor signaling pathway GO:0044708 single-organism behavior GO:0045471 response to ethanol GO:0048013 ephrin receptor signaling pathway GO:0050890 cognition GO:0097305 response to alcohol
Molecular Function	GO:0004970 ionotropic glutamate receptor activity GO:0004972 NMDA glutamate receptor activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0005234 extracellular-glutamate-gated ion channel activity GO:0008066 glutamate receptor activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0016594 glycine binding GO:0016597 amino acid binding GO:0022803 passive transmembrane transporter activity GO:0022824 transmitter-gated ion channel activity GO:0022834 ligand-gated channel activity GO:0022835 transmitter-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0030594 neurotransmitter receptor activity GO:0031406 carboxylic acid binding GO:0043168 anion binding
Cellular Component	GO:0008328 ionotropic glutamate receptor complex GO:0017146 NMDA selective glutamate receptor complex GO:0034702 ion channel complex GO:0043235 receptor complex GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:1902495 transmembrane transporter complex GO:1990351 transporter complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04713 Circadian entrainment hsa04720 Long-term potentiation hsa04724 Glutamatergic synapse hsa04728 Dopaminergic synapse
Reactome	R-HSA-170984: ARMS-mediated activation R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-422475: Axon guidance R-HSA-442729: CREB phosphorylation through the activation of CaMKII R-HSA-442742: CREB phosphorylation through the activation of Ras R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928662: EPHB-mediated forward signaling R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-6794361: Interactions of neurexins and neuroligins at synapses R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-438064: Post NMDA receptor activation events R-HSA-169893: Prolonged ERK activation events R-HSA-6794362: Protein-protein interactions at synapses R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-442982: Ras activation uopn Ca2+ infux through NMDA receptor R-HSA-8849932: SALM protein interactions at the synapses R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-112315: Transmission across Chemical Synapses R-HSA-438066: Unblocking of NMDA receptor, glutamate binding and activation R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04024 cAMP signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04713 Circadian entrainment
hsa04720 Long-term potentiation
hsa04724 Glutamatergic synapse
hsa04728 Dopaminergic synapse

Reactome

R-HSA-170984: ARMS-mediated activation
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events
R-HSA-422475: Axon guidance
R-HSA-442729: CREB phosphorylation through the activation of CaMKII
R-HSA-442742: CREB phosphorylation through the activation of Ras
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-186763: Downstream signal transduction
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-6794361: Interactions of neurexins and neuroligins at synapses
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-112316: Neuronal System
R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
R-HSA-438064: Post NMDA receptor activation events
R-HSA-169893: Prolonged ERK activation events
R-HSA-6794362: Protein-protein interactions at synapses
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-442982: Ras activation uopn Ca2+ infux through NMDA receptor
R-HSA-8849932: SALM protein interactions at the synapses
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-438066: Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GRIN2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of GRIN2B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of GRIN2B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.375	0.0293
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.857	0.204
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.78	0.607
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.218	0.783
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1	0.517
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.488	0.751
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.076	0.849
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.076	0.901
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.224	0.536

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of GRIN2B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	21.4	0	21.4	0.081
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	30	0	30	0.528
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	6.8	8	0.247
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	8.5	6.3	0.453
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	42.9	11.8	31.1	0.07
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	61.5	18.2	43.3	0.0472
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	18.4	3.7	14.7	0.126
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	7.7	5.9	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	25	0	25	0.103
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRIN2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRIN2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRIN2B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRIN2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GRIN2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GRIN2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GRIN2B
Name	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Aliases	GluN2B; NMDAR2B; EIEE27; MRD6; NR2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate re ......
Chromosomal Location	12p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GRIN2B collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting GRIN2B.

ID	Name	Drug Type	Targets	#Targets
DB00142	Glutamic Acid	Small Molecule	AADAT, AASS, ABAT, ALDH18A1, ASNS, BCAT1, BCAT2, CCBL2, CPQ, DNPEP ......	69
DB00289	Atomoxetine	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, SLC6A2, SLC ......	10
DB00312	Pentobarbital	Small Molecule	CHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......	34
DB00418	Secobarbital	Small Molecule	CHRNA4, CHRNA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GR ......	17
DB00454	Pethidine	Small Molecule	CES1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIN1, GRIN2A, GRIN2B, GR ......	16
DB00502	Haloperidol	Small Molecule	DRD1, DRD2, DRD3, GRIN2B, HTR2A, MCHR1, SLC18A2	7
DB00659	Acamprosate	Small Molecule	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......	24
DB00949	Felbamate	Small Molecule	GRIN2A, GRIN2B, GRIN3A	3
DB00996	Gabapentin	Small Molecule	ADORA1, CACNA1B, CACNA2D1, CACNA2D2, GABBR1, GABBR2, GRIN1, GRIN2A ......	13
DB01043	Memantine	Small Molecule	DRD2, GRIN1, GRIN2A, GRIN2B, GRIN3A, HTR3A	6
DB01174	Phenobarbital	Small Molecule	CHRNA4, CHRNA7, GABRA1, GRIA2, GRIK2, GRIN1, GRIN2A, GRIN2B, GRIN2 ......	13
DB01520	Tenocyclidine	Small Molecule	GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B	6
DB01708	Prasterone	Small Molecule	AR, ESR1, ESR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GA ......	33
DB01956	Taurine	Small Molecule	GABBR1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GA ......	21
DB04896	Milnacipran	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, SLC6A2, SLC ......	9
DB05956	EVT-101	Small Molecule	GRIN2B, RXRA	2
DB06151	Acetylcysteine	Small Molecule	ACY1, CHUK, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3A, GSS, IKBKB, SLC ......	10
DB06738	Ketobemidone	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, OPRD1, OPRK ......	10
DB06741	Gavestinel	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B	7
DB08954	Ifenprodil	Small Molecule	GRIN1, GRIN2B	2
DB09409	Magnesium acetate tetrahydrate	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B	7
DB09481	Magnesium carbonate	Small Molecule	GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B	7
DB13146	Fluciclovine (18F)	Small Molecule	GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, ......	14

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