Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Cell junction, synapse, postsynaptic cell membrane Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). |
Domain |
PF00060 Ligand-gated ion channel PF10613 Ligated ion channel L-glutamate- and glycine-binding site |
Function |
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). |
Biological Process |
GO:0001964 startle response GO:0006816 calcium ion transport GO:0007215 glutamate receptor signaling pathway GO:0016358 dendrite development GO:0032102 negative regulation of response to external stimulus GO:0035235 ionotropic glutamate receptor signaling pathway GO:0045471 response to ethanol GO:0050905 neuromuscular process GO:0060134 prepulse inhibition GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:0097305 response to alcohol |
Molecular Function |
GO:0004970 ionotropic glutamate receptor activity GO:0004972 NMDA glutamate receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0005234 extracellular-glutamate-gated ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0008066 glutamate receptor activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0016594 glycine binding GO:0016597 amino acid binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0022803 passive transmembrane transporter activity GO:0022824 transmitter-gated ion channel activity GO:0022834 ligand-gated channel activity GO:0022835 transmitter-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0030594 neurotransmitter receptor activity GO:0031406 carboxylic acid binding GO:0043168 anion binding GO:0046873 metal ion transmembrane transporter activity GO:0051721 protein phosphatase 2A binding GO:0072509 divalent inorganic cation transmembrane transporter activity |
Cellular Component |
GO:0008328 ionotropic glutamate receptor complex GO:0014069 postsynaptic density GO:0017146 NMDA selective glutamate receptor complex GO:0034702 ion channel complex GO:0043025 neuronal cell body GO:0043235 receptor complex GO:0044297 cell body GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:0099572 postsynaptic specialization GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04724 Glutamatergic synapse |
Reactome | - |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GRIN3A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GRIN3A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GRIN3A in various data sets.
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Points in the above scatter plot represent the mutation difference of GRIN3A in various data sets.
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Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRIN3A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRIN3A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRIN3A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRIN3A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GRIN3A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GRIN3A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GRIN3A |
Name | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
Aliases | GluN3A; NMDAR-L; NR3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; glutamate [NMDA] receptor subunit ...... |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GRIN3A collected from DrugBank database. |
Details on drugs targeting GRIN3A.
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