Summary | |
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Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion. |
Domain |
PF00069 Protein kinase domain PF00615 Regulator of G protein signaling domain |
Function |
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). |
Biological Process |
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007217 tachykinin receptor signaling pathway GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0016055 Wnt signaling pathway GO:0045444 fat cell differentiation GO:0046777 protein autophosphorylation GO:0198738 cell-cell signaling by wnt |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004703 G-protein coupled receptor kinase activity GO:0005080 protein kinase C binding GO:0005543 phospholipid binding GO:0047696 beta-adrenergic receptor kinase activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0031965 nuclear membrane |
KEGG |
hsa04062 Chemokine signaling pathway hsa04144 Endocytosis |
Reactome |
R-HSA-416476: G alpha (q) signalling events R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GRK5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GRK5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GRK5 in various data sets.
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Points in the above scatter plot represent the mutation difference of GRK5 in various data sets.
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Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRK5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRK5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRK5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRK5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GRK5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GRK5 |
Name | G protein-coupled receptor kinase 5 |
Aliases | GPRK5; FP2025; g protein-coupled receptor kinase GRK5 |
Chromosomal Location | 10q26.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GRK5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |