Browse GRM6

Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cell projection, dendrite Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Domain PF00003 7 transmembrane sweet-taste receptor of 3 GCPR
PF01094 Receptor family ligand binding region
PF07562 Nine Cysteines Domain of family 3 GPCR
Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0006816 calcium ion transport
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007423 sensory organ development
GO:0007601 visual perception
GO:0007626 locomotory behavior
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
GO:0009584 detection of visible light
GO:0010959 regulation of metal ion transport
GO:0035249 synaptic transmission, glutamatergic
GO:0043010 camera-type eye development
GO:0043270 positive regulation of ion transport
GO:0050804 modulation of synaptic transmission
GO:0050908 detection of light stimulus involved in visual perception
GO:0050953 sensory perception of light stimulus
GO:0050962 detection of light stimulus involved in sensory perception
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060041 retina development in camera-type eye
GO:0070509 calcium ion import
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
Molecular Function GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0001642 group III metabotropic glutamate receptor activity
GO:0008066 glutamate receptor activity
GO:0098988 G-protein coupled glutamate receptor activity
Cellular Component GO:0030425 dendrite
GO:0030427 site of polarized growth
GO:0035838 growing cell tip
GO:0035841 new growing cell tip
GO:0042734 presynaptic membrane
GO:0051286 cell tip
GO:0097060 synaptic membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04724 Glutamatergic synapse
Reactome R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594: G alpha (i) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GRM6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GRM6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA Sensitive to T cell-mediated killing
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GRM6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2840.539
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7620.503
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3120.801
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6760.0296
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GRM6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417011.8-11.80.488
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRM6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRM6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRM6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRM6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GRM6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GRM6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGRM6
Nameglutamate receptor, metabotropic 6
Aliases GPRC1F; mGlu6; MGLUR6; CSNB1B; Metabotropic glutamate receptor 6
Chromosomal Location5q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GRM6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.