Summary | |
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Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00003 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 Receptor family ligand binding region PF07562 Nine Cysteines Domain of family 3 GPCR |
Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. |
Biological Process |
GO:0001661 conditioned taste aversion GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006816 calcium ion transport GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007215 glutamate receptor signaling pathway GO:0007216 G-protein coupled glutamate receptor signaling pathway GO:0007270 neuron-neuron synaptic transmission GO:0007605 sensory perception of sound GO:0007608 sensory perception of smell GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007614 short-term memory GO:0007631 feeding behavior GO:0008306 associative learning GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0014047 glutamate secretion GO:0014048 regulation of glutamate secretion GO:0014050 negative regulation of glutamate secretion GO:0015711 organic anion transport GO:0019226 transmission of nerve impulse GO:0030534 adult behavior GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030800 negative regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030803 negative regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030809 negative regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030815 negative regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030818 negative regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0035249 synaptic transmission, glutamatergic GO:0035637 multicellular organismal signaling GO:0043271 negative regulation of ion transport GO:0044070 regulation of anion transport GO:0044708 single-organism behavior GO:0045980 negative regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046942 carboxylic acid transport GO:0050804 modulation of synaptic transmission GO:0050890 cognition GO:0050954 sensory perception of mechanical stimulus GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051966 regulation of synaptic transmission, glutamatergic GO:0052652 cyclic purine nucleotide metabolic process GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072511 divalent inorganic cation transport GO:0072522 purine-containing compound biosynthetic process GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900372 negative regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1903531 negative regulation of secretion by cell GO:1903792 negative regulation of anion transport |
Molecular Function |
GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity GO:0001642 group III metabotropic glutamate receptor activity GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005245 voltage-gated calcium channel activity GO:0005246 calcium channel regulator activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0008066 glutamate receptor activity GO:0010851 cyclase regulator activity GO:0010854 adenylate cyclase regulator activity GO:0010855 adenylate cyclase inhibitor activity GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0016247 channel regulator activity GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022843 voltage-gated cation channel activity GO:0043177 organic acid binding GO:0046873 metal ion transmembrane transporter activity GO:0070905 serine binding GO:0072509 divalent inorganic cation transmembrane transporter activity GO:0098988 G-protein coupled glutamate receptor activity |
Cellular Component |
GO:0005938 cell cortex GO:0030424 axon GO:0030425 dendrite GO:0032279 asymmetric synapse GO:0042734 presynaptic membrane GO:0043198 dendritic shaft GO:0043235 receptor complex GO:0045211 postsynaptic membrane GO:0048786 presynaptic active zone GO:0097060 synaptic membrane GO:0098793 presynapse GO:0098794 postsynapse GO:0098984 neuron to neuron synapse GO:0099568 cytoplasmic region |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04724 Glutamatergic synapse |
Reactome |
R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GRM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GRM7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GRM7 in various data sets.
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Points in the above scatter plot represent the mutation difference of GRM7 in various data sets.
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Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRM7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GRM7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GRM7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GRM7 |
Name | glutamate receptor, metabotropic 7 |
Aliases | GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ...... |
Chromosomal Location | 3p26-p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GRM7 collected from DrugBank database. |
Details on drugs targeting GRM7.
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