Summary | |
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Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Cytoplasmic vesicle, secretory vesicle lumen |
Domain |
PF02044 Bombesin-like peptide |
Function |
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). |
Biological Process |
GO:0007218 neuropeptide signaling pathway |
Molecular Function |
GO:0005179 hormone activity GO:0005184 neuropeptide hormone activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-400508: Incretin synthesis, secretion, and inactivation R-HSA-392499: Metabolism of proteins R-HSA-2980736: Peptide hormone metabolism R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GRP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GRP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GRP in various data sets.
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Points in the above scatter plot represent the mutation difference of GRP in various data sets.
|
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GRP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GRP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GRP |
Name | gastrin-releasing peptide |
Aliases | bombesin; neuromedin C; prepro-GRP; BN-10; preproGRP; proGRP; pre-progastrin releasing peptide |
Chromosomal Location | 18q21.1-q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GRP collected from DrugBank database. |
There is no record. |