Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. |
Domain |
PF00069 Protein kinase domain |
Function |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). |
Biological Process |
GO:0000271 polysaccharide biosynthetic process GO:0000320 re-entry into mitotic cell cycle GO:0000768 syncytium formation by plasma membrane fusion GO:0001558 regulation of cell growth GO:0001837 epithelial to mesenchymal transition GO:0001952 regulation of cell-matrix adhesion GO:0001954 positive regulation of cell-matrix adhesion GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002067 glandular epithelial cell differentiation GO:0002068 glandular epithelial cell development GO:0003012 muscle system process GO:0003300 cardiac muscle hypertrophy GO:0003309 type B pancreatic cell differentiation GO:0003323 type B pancreatic cell development GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0005979 regulation of glycogen biosynthetic process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006109 regulation of carbohydrate metabolic process GO:0006112 energy reserve metabolic process GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006349 regulation of gene expression by genetic imprinting GO:0006606 protein import into nucleus GO:0006611 protein export from nucleus GO:0006839 mitochondrial transport GO:0006913 nucleocytoplasmic transport GO:0006949 syncytium formation GO:0006983 ER overload response GO:0006984 ER-nucleus signaling pathway GO:0007006 mitochondrial membrane organization GO:0007160 cell-matrix adhesion GO:0007212 dopamine receptor signaling pathway GO:0007409 axonogenesis GO:0007520 myoblast fusion GO:0007623 circadian rhythm GO:0008361 regulation of cell size GO:0008637 apoptotic mitochondrial changes GO:0009250 glucan biosynthetic process GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0010611 regulation of cardiac muscle hypertrophy GO:0010614 negative regulation of cardiac muscle hypertrophy GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0010906 regulation of glucose metabolic process GO:0010962 regulation of glucan biosynthetic process GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014041 regulation of neuron maturation GO:0014043 negative regulation of neuron maturation GO:0014741 negative regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014902 myotube differentiation GO:0015980 energy derivation by oxidation of organic compounds GO:0016049 cell growth GO:0016051 carbohydrate biosynthetic process GO:0016055 Wnt signaling pathway GO:0017038 protein import GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0019318 hexose metabolic process GO:0021537 telencephalon development GO:0021543 pallium development GO:0021700 developmental maturation GO:0021761 limbic system development GO:0021766 hippocampus development GO:0021987 cerebral cortex development GO:0022604 regulation of cell morphogenesis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030307 positive regulation of cell growth GO:0030516 regulation of axon extension GO:0030856 regulation of epithelial cell differentiation GO:0030857 negative regulation of epithelial cell differentiation GO:0030900 forebrain development GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031333 negative regulation of protein complex assembly GO:0031334 positive regulation of protein complex assembly GO:0031345 negative regulation of cell projection organization GO:0031346 positive regulation of cell projection organization GO:0031589 cell-substrate adhesion GO:0032091 negative regulation of protein binding GO:0032092 positive regulation of protein binding GO:0032259 methylation GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032535 regulation of cellular component size GO:0032881 regulation of polysaccharide metabolic process GO:0032885 regulation of polysaccharide biosynthetic process GO:0032886 regulation of microtubule-based process GO:0032984 macromolecular complex disassembly GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033692 cellular polysaccharide biosynthetic process GO:0034504 protein localization to nucleus GO:0034605 cellular response to heat GO:0034637 cellular carbohydrate biosynthetic process GO:0034976 response to endoplasmic reticulum stress GO:0035270 endocrine system development GO:0035372 protein localization to microtubule GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035794 positive regulation of mitochondrial membrane permeability GO:0035883 enteroendocrine cell differentiation GO:0036015 response to interleukin-3 GO:0036016 cellular response to interleukin-3 GO:0038034 signal transduction in absence of ligand GO:0040029 regulation of gene expression, epigenetic GO:0042176 regulation of protein catabolic process GO:0042306 regulation of protein import into nucleus GO:0042308 negative regulation of protein import into nucleus GO:0042551 neuron maturation GO:0042692 muscle cell differentiation GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042992 negative regulation of transcription factor import into nucleus GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043241 protein complex disassembly GO:0043254 regulation of protein complex assembly GO:0043255 regulation of carbohydrate biosynthetic process GO:0043393 regulation of protein binding GO:0043414 macromolecule methylation GO:0043467 regulation of generation of precursor metabolites and energy GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0044026 DNA hypermethylation GO:0044027 hypermethylation of CpG island GO:0044030 regulation of DNA methylation GO:0044042 glucan metabolic process GO:0044057 regulation of system process GO:0044089 positive regulation of cellular component biogenesis GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process GO:0044380 protein localization to cytoskeleton GO:0044723 single-organism carbohydrate metabolic process GO:0044728 DNA methylation or demethylation GO:0044744 protein targeting to nucleus GO:0045444 fat cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045719 negative regulation of glycogen biosynthetic process GO:0045732 positive regulation of protein catabolic process GO:0045773 positive regulation of axon extension GO:0045785 positive regulation of cell adhesion GO:0045862 positive regulation of proteolysis GO:0045912 negative regulation of carbohydrate metabolic process GO:0045927 positive regulation of growth GO:0046777 protein autophosphorylation GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046827 positive regulation of protein export from nucleus GO:0046902 regulation of mitochondrial membrane permeability GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051146 striated muscle cell differentiation GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051348 negative regulation of transferase activity GO:0051531 NFAT protein import into nucleus GO:0051532 regulation of NFAT protein import into nucleus GO:0051534 negative regulation of NFAT protein import into nucleus GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0060070 canonical Wnt signaling pathway GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0060828 regulation of canonical Wnt signaling pathway GO:0061136 regulation of proteasomal protein catabolic process GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070873 regulation of glycogen metabolic process GO:0070874 negative regulation of glycogen metabolic process GO:0070997 neuron death GO:0071109 superior temporal gyrus development GO:0071216 cellular response to biotic stimulus GO:0071514 genetic imprinting GO:0071542 dopaminergic neuron differentiation GO:0072698 protein localization to microtubule cytoskeleton GO:0090066 regulation of anatomical structure size GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090257 regulation of muscle system process GO:0090316 positive regulation of intracellular protein transport GO:0090317 negative regulation of intracellular protein transport GO:0090559 regulation of membrane permeability GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097193 intrinsic apoptotic signaling pathway GO:0097345 mitochondrial outer membrane permeabilization GO:0099565 chemical synaptic transmission, postsynaptic GO:0198738 cell-cell signaling by wnt GO:1900034 regulation of cellular response to heat GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901800 positive regulation of proteasomal protein catabolic process GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902593 single-organism nuclear import GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903429 regulation of cell maturation GO:1903430 negative regulation of cell maturation GO:1903533 regulation of protein targeting GO:1903828 negative regulation of cellular protein localization GO:1903829 positive regulation of cellular protein localization GO:1904338 regulation of dopaminergic neuron differentiation GO:1904339 negative regulation of dopaminergic neuron differentiation GO:1904589 regulation of protein import GO:1904590 negative regulation of protein import GO:1904885 beta-catenin destruction complex assembly GO:1904886 beta-catenin destruction complex disassembly GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:1990138 neuron projection extension GO:2000074 regulation of type B pancreatic cell development GO:2000077 negative regulation of type B pancreatic cell development GO:2000465 regulation of glycogen (starch) synthase activity GO:2000466 negative regulation of glycogen (starch) synthase activity GO:2000736 regulation of stem cell differentiation GO:2000738 positive regulation of stem cell differentiation GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0001085 RNA polymerase II transcription factor binding GO:0002039 p53 binding GO:0004674 protein serine/threonine kinase activity GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0031625 ubiquitin protein ligase binding GO:0034236 protein kinase A catalytic subunit binding GO:0044389 ubiquitin-like protein ligase binding GO:0050321 tau-protein kinase activity GO:0051018 protein kinase A binding GO:0051059 NF-kappaB binding |
Cellular Component |
GO:0005813 centrosome GO:0030425 dendrite GO:0030426 growth cone GO:0030427 site of polarized growth GO:0030877 beta-catenin destruction complex GO:0043025 neuronal cell body GO:0043198 dendritic shaft GO:0044297 cell body GO:0098794 postsynapse GO:1990909 Wnt signalosome |
KEGG |
hsa04012 ErbB signaling pathway hsa04062 Chemokine signaling pathway hsa04110 Cell cycle hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04310 Wnt signaling pathway hsa04340 Hedgehog signaling pathway hsa04360 Axon guidance hsa04390 Hippo signaling pathway hsa04510 Focal adhesion hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04722 Neurotrophin signaling pathway hsa04728 Dopaminergic synapse hsa04910 Insulin signaling pathway hsa04916 Melanogenesis hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-198323: AKT phosphorylates targets in the cytosol R-HSA-4839748: AMER1 mutants destabilize the destruction complex R-HSA-5467337: APC truncation mutants have impaired AXIN binding R-HSA-5467340: AXIN missense mutants destabilize the destruction complex R-HSA-4839735: AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-196299: Beta-catenin phosphorylation cascade R-HSA-399956: CRMPs in Sema3A signaling R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-5610783: Degradation of GLI2 by the proteasome R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-1266738: Developmental Biology R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-212165: Epigenetic regulation of gene expression R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-180292: GAB1 signalosome R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome R-HSA-74160: Gene Expression R-HSA-5610787: Hedgehog 'off' state R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-3371453: Regulation of HSF1-mediated heat shock response R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-5358351: Signaling by Hedgehog R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-4791275: Signaling by WNT in cancer R-HSA-195721: Signaling by Wnt R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-4839744: truncated APC mutants destabilize the destruction complex |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GSK3B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GSK3B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GSK3B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GSK3B in various data sets.
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Points in the above scatter plot represent the mutation difference of GSK3B in various data sets.
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Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GSK3B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GSK3B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GSK3B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GSK3B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GSK3B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GSK3B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GSK3B |
Name | glycogen synthase kinase 3 beta |
Aliases | GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta |
Chromosomal Location | 3q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GSK3B collected from DrugBank database. |
Details on drugs targeting GSK3B.
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