Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF14497 Glutathione S-transferase PF02798 Glutathione S-transferase |
Function |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. |
Biological Process |
GO:0006575 cellular modified amino acid metabolic process GO:0006749 glutathione metabolic process GO:0006790 sulfur compound metabolic process GO:0044272 sulfur compound biosynthetic process GO:1901685 glutathione derivative metabolic process GO:1901687 glutathione derivative biosynthetic process |
Molecular Function |
GO:0004364 glutathione transferase activity GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups |
Cellular Component | - |
KEGG |
hsa00480 Glutathione metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-156590: Glutathione conjugation R-HSA-1430728: Metabolism R-HSA-156580: Phase II conjugation |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GSTA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GSTA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GSTA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GSTA2 in various data sets.
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Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GSTA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GSTA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GSTA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GSTA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GSTA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GSTA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GSTA2 |
Name | glutathione S-transferase alpha 2 |
Aliases | glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ...... |
Chromosomal Location | 6p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GSTA2 collected from DrugBank database. |
Details on drugs targeting GSTA2.
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