Browse GSTA2

Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF14497 Glutathione S-transferase
PF02798 Glutathione S-transferase
Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

> Gene Ontology
 
Biological Process GO:0006575 cellular modified amino acid metabolic process
GO:0006749 glutathione metabolic process
GO:0006790 sulfur compound metabolic process
GO:0044272 sulfur compound biosynthetic process
GO:1901685 glutathione derivative metabolic process
GO:1901687 glutathione derivative biosynthetic process
Molecular Function GO:0004364 glutathione transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00480 Glutathione metabolism
hsa00980 Metabolism of xenobiotics by cytochrome P450
hsa00982 Drug metabolism - cytochrome P450
Reactome R-HSA-211859: Biological oxidations
R-HSA-156590: Glutathione conjugation
R-HSA-1430728: Metabolism
R-HSA-156580: Phase II conjugation
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GSTA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GSTA2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GSTA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5120.36
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2870.754
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.1060.17
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4590.658
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2010.404
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.540.143
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3730.699
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4320.82
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.5090.41
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.390.861
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2360.938
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.0280.0118
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GSTA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GSTA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GSTA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GSTA2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GSTA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GSTA2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GSTA2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGSTA2
Nameglutathione S-transferase alpha 2
Aliases glutathione S-transferase A2; GST2-2; GTA2; GTH2; GST HA subunit 2; GST class-alpha member 2; GST-gamma; S-( ......
Chromosomal Location6p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GSTA2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GSTA2.
ID Name Drug Type Targets #Targets
DB00143GlutathioneSmall MoleculeAKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......41
DB00608ChloroquineSmall MoleculeGSTA2, TLR9, TNF3