Summary | |
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Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF02270 Transcription initiation factor IIF |
Function |
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006352 DNA-templated transcription, initiation GO:0006354 DNA-templated transcription, elongation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006370 7-methylguanosine mRNA capping GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0008543 fibroblast growth factor receptor signaling pathway GO:0009301 snRNA transcription GO:0009452 7-methylguanosine RNA capping GO:0016073 snRNA metabolic process GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0031334 positive regulation of protein complex assembly GO:0032784 regulation of DNA-templated transcription, elongation GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0034243 regulation of transcription elongation from RNA polymerase II promoter GO:0036260 RNA capping GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0043254 regulation of protein complex assembly GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0044089 positive regulation of cellular component biogenesis GO:0044344 cellular response to fibroblast growth factor stimulus GO:0046782 regulation of viral transcription GO:0048524 positive regulation of viral process GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:0060260 regulation of transcription initiation from RNA polymerase II promoter GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter GO:0071774 response to fibroblast growth factor GO:0098781 ncRNA transcription GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation |
Molecular Function |
GO:0000990 transcription factor activity, core RNA polymerase binding GO:0000991 transcription factor activity, core RNA polymerase II binding GO:0004386 helicase activity |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005674 transcription factor TFIIF complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-167242: Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-112387: Elongation arrest and recovery R-HSA-6803529: FGFR2 alternative splicing R-HSA-1839126: FGFR2 mutant receptor activation R-HSA-167152: Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200: Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-112382: Formation of RNA Pol II elongation complex R-HSA-113418: Formation of the Early Elongation Complex R-HSA-167158: Formation of the HIV-1 Early Elongation Complex R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167169: HIV Transcription Elongation R-HSA-167161: HIV Transcription Initiation R-HSA-167287: HIV elongation arrest and recovery R-HSA-5663205: Infectious disease R-HSA-168254: Influenza Infection R-HSA-168255: Influenza Life Cycle R-HSA-168273: Influenza Viral RNA Transcription and Replication R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167290: Pausing and recovery of HIV elongation R-HSA-167238: Pausing and recovery of Tat-mediated HIV elongation R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-77075: RNA Pol II CTD phosphorylation and interaction with CE R-HSA-167160: RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167162: RNA Polymerase II HIV Promoter Escape R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73776: RNA Polymerase II Promoter Escape R-HSA-73857: RNA Polymerase II Transcription R-HSA-75955: RNA Polymerase II Transcription Elongation R-HSA-75953: RNA Polymerase II Transcription Initiation R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-6807505: RNA polymerase II transcribes snRNA genes R-HSA-162582: Signal Transduction R-HSA-190236: Signaling by FGFR R-HSA-1226099: Signaling by FGFR in disease R-HSA-5654738: Signaling by FGFR2 R-HSA-8851708: Signaling by FGFR2 IIIa TM R-HSA-5655253: Signaling by FGFR2 in disease R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-167243: Tat-mediated HIV elongation arrest and recovery R-HSA-167246: Tat-mediated elongation of the HIV-1 transcript R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-168325: Viral Messenger RNA Synthesis R-HSA-72086: mRNA Capping R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway R-HSA-72165: mRNA Splicing - Minor Pathway |
Summary | |
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Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GTF2F2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GTF2F2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GTF2F2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GTF2F2 in various data sets.
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Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GTF2F2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GTF2F2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GTF2F2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GTF2F2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GTF2F2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GTF2F2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GTF2F2 |
Name | general transcription factor IIF, polypeptide 2, 30kDa |
Aliases | RAP30; TF2F2; ATP-dependent helicase GTF2F2; TFIIF-beta; general transcription factor IIF 30 kDa subunit; tr ...... |
Chromosomal Location | 13q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GTF2F2 collected from DrugBank database. |
There is no record. |