Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform alpha: Secreted. Cytoplasmic granule. |
Domain |
PF00089 Trypsin |
Function |
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
Biological Process |
GO:0019835 cytolysis GO:0032069 regulation of nuclease activity GO:0032070 regulation of deoxyribonuclease activity GO:0032071 regulation of endodeoxyribonuclease activity GO:0032074 negative regulation of nuclease activity GO:0032076 negative regulation of deoxyribonuclease activity GO:0032078 negative regulation of endodeoxyribonuclease activity GO:0043392 negative regulation of DNA binding GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051341 regulation of oxidoreductase activity GO:0051346 negative regulation of hydrolase activity GO:0051354 negative regulation of oxidoreductase activity |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0001772 immunological synapse |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction |
Reactome | - |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GZMA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GZMA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GZMA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GZMA in various data sets.
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Points in the above scatter plot represent the mutation difference of GZMA in various data sets.
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Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GZMA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GZMA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GZMA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GZMA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GZMA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GZMA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GZMA |
Name | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Aliases | CTL tryptase; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine proteas ...... |
Chromosomal Location | 5q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GZMA collected from DrugBank database. |
There is no record. |