Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic granule Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells. |
Domain |
PF00089 Trypsin |
Function |
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
Biological Process |
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0008637 apoptotic mitochondrial changes GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016485 protein processing GO:0019835 cytolysis GO:0035794 positive regulation of mitochondrial membrane permeability GO:0042267 natural killer cell mediated cytotoxicity GO:0046902 regulation of mitochondrial membrane permeability GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0051604 protein maturation GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090559 regulation of membrane permeability GO:0097345 mitochondrial outer membrane permeabilization GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0001772 immunological synapse |
KEGG |
hsa04210 Apoptosis hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-75108: Activation, myristolyation of BID and translocation to mitochondria R-HSA-109581: Apoptosis R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-2197563: NOTCH2 intracellular domain regulates transcription R-HSA-5357801: Programmed Cell Death R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980145: Signaling by NOTCH2 |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GZMB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GZMB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GZMB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GZMB in various data sets.
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Points in the above scatter plot represent the mutation difference of GZMB in various data sets.
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Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GZMB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GZMB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GZMB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GZMB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GZMB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GZMB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GZMB |
Name | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Aliases | CCPI; CGL-1; CSP-B; CGL1; CTSGL1; SECT; fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cel ...... |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GZMB collected from DrugBank database. |
There is no record. |