Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Chromosome. |
Domain |
PF00125 Core histone H2A/H2B/H3/H4 PF16211 C-terminus of histone H2A |
Function |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. |
Biological Process |
GO:0006342 chromatin silencing GO:0016458 gene silencing GO:0032355 response to estradiol GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000785 chromatin GO:0000786 nucleosome GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0005719 nuclear euchromatin GO:0005720 nuclear heterochromatin GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0044815 DNA packaging complex |
KEGG | - |
Reactome |
R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-977225: Amyloid fiber formation R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-73886: Chromosome Maintenance R-HSA-2299718: Condensation of Prophase Chromosomes R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-5334118: DNA methylation R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-1266738: Developmental Biology R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-201722: Formation of the beta-catenin R-HSA-74160: Gene Expression R-HSA-211000: Gene Silencing by RNA R-HSA-68886: M Phase R-HSA-1500620: Meiosis R-HSA-912446: Meiotic recombination R-HSA-1221632: Meiotic synapsis R-HSA-392499: Metabolism of proteins R-HSA-68875: Mitotic Prophase R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-774815: Nucleosome assembly R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-212300: PRC2 methylates histones and DNA R-HSA-171306: Packaging Of Telomere Ends R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-3214858: RMTs methylate histone arginines R-HSA-73777: RNA Polymerase I Chain Elongation R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73728: RNA Polymerase I Promoter Opening R-HSA-73864: RNA Polymerase I Transcription R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-427359: SIRT1 negatively regulates rRNA Expression R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-157579: Telomere Maintenance R-HSA-5578749: Transcriptional regulation by small RNAs |
Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between H2AFZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of H2AFZ in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of H2AFZ in various data sets.
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Points in the above scatter plot represent the mutation difference of H2AFZ in various data sets.
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Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of H2AFZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of H2AFZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by H2AFZ. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of H2AFZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of H2AFZ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | H2AFZ |
Name | H2A histone family, member Z |
Aliases | H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z |
Chromosomal Location | 4q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between H2AFZ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |