Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Chromosome. |
Domain |
PF00125 Core histone H2A/H2B/H3/H4 |
Function |
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Biological Process |
GO:0000183 chromatin silencing at rDNA GO:0001503 ossification GO:0001558 regulation of cell growth GO:0001649 osteoblast differentiation GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006997 nucleus organization GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007292 female gamete generation GO:0007338 single fertilization GO:0007548 sex differentiation GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008406 gonad development GO:0008584 male gonad development GO:0009566 fertilization GO:0010639 negative regulation of organelle organization GO:0016049 cell growth GO:0016458 gene silencing GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030261 chromosome condensation GO:0030307 positive regulation of cell growth GO:0031047 gene silencing by RNA GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0031507 heterochromatin assembly GO:0031508 pericentric heterochromatin assembly GO:0031509 telomeric heterochromatin assembly GO:0032200 telomere organization GO:0033044 regulation of chromosome organization GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0035264 multicellular organism growth GO:0040029 regulation of gene expression, epigenetic GO:0042692 muscle cell differentiation GO:0044706 multi-multicellular organism process GO:0045137 development of primary sexual characteristics GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0045927 positive regulation of growth GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048232 male gamete generation GO:0048477 oogenesis GO:0048515 spermatid differentiation GO:0048608 reproductive structure development GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0060623 regulation of chromosome condensation GO:0061458 reproductive system development GO:0065004 protein-DNA complex assembly GO:0070828 heterochromatin organization GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:0090230 regulation of centromere complex assembly GO:1902340 negative regulation of chromosome condensation GO:2001251 negative regulation of chromosome organization |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001158 enhancer sequence-specific DNA binding GO:0003682 chromatin binding GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0042393 histone binding GO:0043566 structure-specific DNA binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000786 nucleosome GO:0000788 nuclear nucleosome GO:0000790 nuclear chromatin GO:0000803 sex chromosome GO:0000805 X chromosome GO:0001740 Barr body GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0044815 DNA packaging complex GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-977225: Amyloid fiber formation R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-2299718: Condensation of Prophase Chromosomes R-HSA-5334118: DNA methylation R-HSA-1266738: Developmental Biology R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-201722: Formation of the beta-catenin R-HSA-74160: Gene Expression R-HSA-211000: Gene Silencing by RNA R-HSA-109582: Hemostasis R-HSA-68886: M Phase R-HSA-1500620: Meiosis R-HSA-912446: Meiotic recombination R-HSA-392499: Metabolism of proteins R-HSA-68875: Mitotic Prophase R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-212300: PRC2 methylates histones and DNA R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-73777: RNA Polymerase I Chain Elongation R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73728: RNA Polymerase I Promoter Opening R-HSA-73864: RNA Polymerase I Transcription R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-427359: SIRT1 negatively regulates rRNA Expression R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5578749: Transcriptional regulation by small RNAs |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between H3F3A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of H3F3A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of H3F3A in various data sets.
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Points in the above scatter plot represent the mutation difference of H3F3A in various data sets.
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Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of H3F3A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of H3F3A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by H3F3A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of H3F3A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of H3F3A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | H3F3A |
Name | H3 histone, family 3A |
Aliases | H3.3A; H3F3 |
Chromosomal Location | 1q42.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between H3F3A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |