Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Mitochondrion matrix ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm |
Domain |
PF16123 Hydroxyacylglutathione hydrolase C-terminus PF00753 Metallo-beta-lactamase superfamily |
Function |
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. |
Biological Process |
GO:0006081 cellular aldehyde metabolic process GO:0006089 lactate metabolic process GO:0006090 pyruvate metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006749 glutathione metabolic process GO:0006750 glutathione biosynthetic process GO:0006790 sulfur compound metabolic process GO:0009438 methylglyoxal metabolic process GO:0019184 nonribosomal peptide biosynthetic process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0042180 cellular ketone metabolic process GO:0042182 ketone catabolic process GO:0042398 cellular modified amino acid biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:0044282 small molecule catabolic process GO:0046185 aldehyde catabolic process GO:0051596 methylglyoxal catabolic process GO:0061727 methylglyoxal catabolic process to lactate |
Molecular Function |
GO:0004416 hydroxyacylglutathione hydrolase activity GO:0016790 thiolester hydrolase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00620 Pyruvate metabolism |
Reactome |
R-HSA-1430728: Metabolism R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HAGH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of HAGH in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HAGH in various data sets.
|
There is no record. |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HAGH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HAGH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HAGH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HAGH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HAGH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HAGH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HAGH |
Name | hydroxyacylglutathione hydrolase |
Aliases | GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HAGH collected from DrugBank database. |
Details on drugs targeting HAGH.
|