Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF07686 Immunoglobulin V-set domain PF00193 Extracellular link domain |
Function |
Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001885 endothelial cell development GO:0002064 epithelial cell development GO:0003158 endothelium development GO:0007422 peripheral nervous system development GO:0008065 establishment of blood-nerve barrier GO:0030198 extracellular matrix organization GO:0043062 extracellular structure organization GO:0045446 endothelial cell differentiation GO:0085029 extracellular matrix assembly |
Molecular Function |
GO:0005201 extracellular matrix structural constituent GO:0005539 glycosaminoglycan binding GO:0005540 hyaluronic acid binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HAPLN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HAPLN2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HAPLN2 in various data sets.
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Points in the above scatter plot represent the mutation difference of HAPLN2 in various data sets.
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Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HAPLN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HAPLN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HAPLN2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HAPLN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HAPLN2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HAPLN2 |
Name | hyaluronan and proteoglycan link protein 2 |
Aliases | BRAL1; brain link protein 1; brain link protein-1 |
Chromosomal Location | 1q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HAPLN2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |