Summary | |
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Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain | - |
Function |
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity). |
Biological Process |
GO:0000271 polysaccharide biosynthetic process GO:0001667 ameboidal-type cell migration GO:0005976 polysaccharide metabolic process GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0010764 negative regulation of fibroblast migration GO:0016051 carbohydrate biosynthetic process GO:0030198 extracellular matrix organization GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030213 hyaluronan biosynthetic process GO:0030336 negative regulation of cell migration GO:0033692 cellular polysaccharide biosynthetic process GO:0034637 cellular carbohydrate biosynthetic process GO:0036119 response to platelet-derived growth factor GO:0036120 cellular response to platelet-derived growth factor stimulus GO:0040013 negative regulation of locomotion GO:0042698 ovulation cycle GO:0043062 extracellular structure organization GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044849 estrous cycle GO:0045226 extracellular polysaccharide biosynthetic process GO:0046379 extracellular polysaccharide metabolic process GO:0048511 rhythmic process GO:0051271 negative regulation of cellular component movement GO:0085029 extracellular matrix assembly GO:1903510 mucopolysaccharide metabolic process GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0008194 UDP-glycosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0050501 hyaluronan synthase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2142850: Hyaluronan biosynthesis and export R-HSA-2142845: Hyaluronan metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HAS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HAS1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HAS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HAS1 in various data sets.
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Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HAS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HAS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HAS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HAS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HAS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HAS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HAS1 |
Name | hyaluronan synthase 1 |
Aliases | HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; HuHAS1 |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HAS1 collected from DrugBank database. |
There is no record. |