Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Cell junction Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). |
Biological Process |
GO:0001771 immunological synapse formation GO:0001773 myeloid dendritic cell activation GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001911 negative regulation of leukocyte mediated cytotoxicity GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002228 natural killer cell mediated immunity GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002281 macrophage activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002347 response to tumor cell GO:0002366 leukocyte activation involved in immune response GO:0002418 immune response to tumor cell GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002423 natural killer cell mediated immune response to tumor cell GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002461 tolerance induction dependent upon immune response GO:0002507 tolerance induction GO:0002519 natural killer cell tolerance induction GO:0002643 regulation of tolerance induction GO:0002652 regulation of tolerance induction dependent upon immune response GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002716 negative regulation of natural killer cell mediated immunity GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002825 regulation of T-helper 1 type immune response GO:0002826 negative regulation of T-helper 1 type immune response GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002834 regulation of response to tumor cell GO:0002835 negative regulation of response to tumor cell GO:0002837 regulation of immune response to tumor cell GO:0002838 negative regulation of immune response to tumor cell GO:0002855 regulation of natural killer cell mediated immune response to tumor cell GO:0002856 negative regulation of natural killer cell mediated immune response to tumor cell GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007565 female pregnancy GO:0008037 cell recognition GO:0009306 protein secretion GO:0009988 cell-cell recognition GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030101 natural killer cell activation GO:0030885 regulation of myeloid dendritic cell activation GO:0030886 negative regulation of myeloid dendritic cell activation GO:0031341 regulation of cell killing GO:0031342 negative regulation of cell killing GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032479 regulation of type I interferon production GO:0032480 negative regulation of type I interferon production GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032609 interferon-gamma production GO:0032612 interleukin-1 production GO:0032623 interleukin-2 production GO:0032632 interleukin-3 production GO:0032633 interleukin-4 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032647 regulation of interferon-alpha production GO:0032649 regulation of interferon-gamma production GO:0032652 regulation of interleukin-1 production GO:0032663 regulation of interleukin-2 production GO:0032672 regulation of interleukin-3 production GO:0032673 regulation of interleukin-4 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032687 negative regulation of interferon-alpha production GO:0032689 negative regulation of interferon-gamma production GO:0032703 negative regulation of interleukin-2 production GO:0032712 negative regulation of interleukin-3 production GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032729 positive regulation of interferon-gamma production GO:0032732 positive regulation of interleukin-1 production GO:0032753 positive regulation of interleukin-4 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032814 regulation of natural killer cell activation GO:0032815 negative regulation of natural killer cell activation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0034138 toll-like receptor 3 signaling pathway GO:0034154 toll-like receptor 7 signaling pathway GO:0034162 toll-like receptor 9 signaling pathway GO:0036301 macrophage colony-stimulating factor production GO:0038061 NIK/NF-kappaB signaling GO:0042088 T-helper 1 type immune response GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042116 macrophage activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042742 defense response to bacterium GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043410 positive regulation of MAPK cascade GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044706 multi-multicellular organism process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045785 positive regulation of cell adhesion GO:0045824 negative regulation of innate immune response GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0046651 lymphocyte proliferation GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050777 negative regulation of immune response GO:0050830 defense response to Gram-positive bacterium GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051047 positive regulation of secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060135 maternal process involved in female pregnancy GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0071611 granulocyte colony-stimulating factor production GO:0071655 regulation of granulocyte colony-stimulating factor production GO:0071656 negative regulation of granulocyte colony-stimulating factor production GO:0071706 tumor necrosis factor superfamily cytokine production GO:0098542 defense response to other organism GO:1900424 regulation of defense response to bacterium GO:1900425 negative regulation of defense response to bacterium GO:1900426 positive regulation of defense response to bacterium GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901256 regulation of macrophage colony-stimulating factor production GO:1901257 negative regulation of macrophage colony-stimulating factor production GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904467 regulation of tumor necrosis factor secretion GO:1904469 positive regulation of tumor necrosis factor secretion GO:1904951 positive regulation of establishment of protein localization GO:1990774 tumor necrosis factor secretion GO:2000520 regulation of immunological synapse formation GO:2000521 negative regulation of immunological synapse formation GO:2001188 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
Molecular Function | - |
Cellular Component |
GO:0001772 immunological synapse GO:0005769 early endosome |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-451927: Interleukin-2 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HAVCR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HAVCR2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HAVCR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HAVCR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of HAVCR2 in various data sets.
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Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HAVCR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HAVCR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HAVCR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HAVCR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HAVCR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HAVCR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HAVCR2 |
Name | hepatitis A virus cellular receptor 2 |
Aliases | Tim-3; TIM3; FLJ14428; TIMD3; CD366; T-cell immunoglobulin mucin family member 3; HAVcr-2; KIM-3; TIMD-3; T ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HAVCR2 collected from DrugBank database. |
There is no record. |