Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein. |
Domain |
PF00008 EGF-like domain |
Function |
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
Biological Process |
GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0002011 morphogenesis of an epithelial sheet GO:0003013 circulatory system process GO:0003015 heart process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0007173 epidermal growth factor receptor signaling pathway GO:0007517 muscle organ development GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010559 regulation of glycoprotein biosynthetic process GO:0010561 negative regulation of glycoprotein biosynthetic process GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0016049 cell growth GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030258 lipid modification GO:0030307 positive regulation of cell growth GO:0030335 positive regulation of cell migration GO:0033002 muscle cell proliferation GO:0035313 wound healing, spreading of epidermal cells GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0040017 positive regulation of locomotion GO:0043491 protein kinase B signaling GO:0044057 regulation of system process GO:0044319 wound healing, spreading of cells GO:0045927 positive regulation of growth GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0051272 positive regulation of cellular component movement GO:0051541 elastin metabolic process GO:0051542 elastin biosynthetic process GO:0051543 regulation of elastin biosynthetic process GO:0051545 negative regulation of elastin biosynthetic process GO:0051546 keratinocyte migration GO:0051547 regulation of keratinocyte migration GO:0051549 positive regulation of keratinocyte migration GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0060047 heart contraction GO:0060326 cell chemotaxis GO:0061041 regulation of wound healing GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090303 positive regulation of wound healing GO:0090504 epiboly GO:0090505 epiboly involved in wound healing GO:1903018 regulation of glycoprotein metabolic process GO:1903019 negative regulation of glycoprotein metabolic process GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903522 regulation of blood circulation GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005154 epidermal growth factor receptor binding GO:0005539 glycosaminoglycan binding GO:0008083 growth factor activity GO:0008201 heparin binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0070851 growth factor receptor binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0045334 clathrin-coated endocytic vesicle |
KEGG |
hsa04012 ErbB signaling pathway hsa04912 GnRH signaling pathway hsa04915 Estrogen signaling pathway |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-8863795: Downregulation of ERBB2 signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2179392: EGFR Transactivation by Gastrin R-HSA-8847993: ERBB2 Activates PTK6 Signaling R-HSA-6785631: ERBB2 Regulates Cell Motility R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-1963640: GRB2 events in ERBB2 signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-1251985: Nuclear signaling by ERBB4 R-HSA-1963642: PI3K events in ERBB2 signaling R-HSA-1250342: PI3K events in ERBB4 signaling R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-8857538: PTK6 promotes HIF1A stabilization R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-180336: SHC1 events in EGFR signaling R-HSA-1250196: SHC1 events in ERBB2 signaling R-HSA-1250347: SHC1 events in ERBB4 signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-1227986: Signaling by ERBB2 R-HSA-1236394: Signaling by ERBB4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-8848021: Signaling by PTK6 R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-5339562: Uptake and actions of bacterial toxins R-HSA-5336415: Uptake and function of diphtheria toxin R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HBEGF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HBEGF and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HBEGF in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HBEGF in various data sets.
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Points in the above scatter plot represent the mutation difference of HBEGF in various data sets.
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Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HBEGF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HBEGF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HBEGF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HBEGF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HBEGF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HBEGF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HBEGF |
Name | heparin-binding EGF-like growth factor |
Aliases | Diphtheria toxin receptor (heparin-binding EGF-like growth factor); heparin-binding epidermal growth factor; ...... |
Chromosomal Location | 5q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HBEGF collected from DrugBank database. |
There is no record. |