Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00042 Globin |
Function |
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. |
Biological Process |
GO:0007596 blood coagulation GO:0007599 hemostasis GO:0015669 gas transport GO:0015671 oxygen transport GO:0050817 coagulation GO:0050878 regulation of body fluid levels |
Molecular Function |
GO:0005344 oxygen transporter activity GO:0005506 iron ion binding GO:0019825 oxygen binding GO:0020037 heme binding GO:0046906 tetrapyrrole binding |
Cellular Component |
GO:0005833 hemoglobin complex GO:0044445 cytosolic part GO:0072562 blood microparticle |
KEGG | - |
Reactome |
R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-109582: Hemostasis |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HBG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of HBG2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HBG2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of HBG2 in various data sets.
|
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HBG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HBG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HBG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HBG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HBG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HBG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HBG2 |
Name | hemoglobin, gamma G |
Aliases | HBG-T1; TNCY; G-gamma globin Paulinia; abnormal hemoglobin; gamma-2-globin; hb F Ggamma; hemoglobin gamma-2 ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HBG2 collected from DrugBank database. |
There is no record. |