Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00042 Globin |
Function |
- |
Biological Process |
GO:0015669 gas transport GO:0015671 oxygen transport |
Molecular Function |
GO:0005344 oxygen transporter activity GO:0005506 iron ion binding GO:0019825 oxygen binding GO:0020037 heme binding GO:0046906 tetrapyrrole binding |
Cellular Component |
GO:0005833 hemoglobin complex GO:0044445 cytosolic part |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HBM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HBM in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HBM in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HBM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HBM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HBM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HBM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HBM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HBM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HBM |
Name | hemoglobin, mu |
Aliases | HBK; HBAP2; hemoglobin, alpha pseudogene 2; alpha globin pseudogene 2; hemoglobin mu chain; mu-globin; Hemog ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HBM collected from DrugBank database. |
There is no record. |