Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04024 cAMP signaling pathway |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-3296197: Hydroxycarboxylic acid-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HCAR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HCAR3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HCAR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of HCAR3 in various data sets.
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Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HCAR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HCAR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HCAR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HCAR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HCAR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HCAR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HCAR3 |
Name | hydroxycarboxylic acid receptor 3 |
Aliases | HM74; GPR109B; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor ...... |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HCAR3 collected from DrugBank database. |
Details on drugs targeting HCAR3.
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