Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Note=Predominantly nuclear. |
Domain |
PF00850 Histone deacetylase domain |
Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
Biological Process |
GO:0006476 protein deacetylation GO:0010001 glial cell differentiation GO:0014003 oligodendrocyte development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0021782 glial cell development GO:0035601 protein deacylation GO:0042063 gliogenesis GO:0048709 oligodendrocyte differentiation GO:0070932 histone H3 deacetylation GO:0098732 macromolecule deacylation |
Molecular Function |
GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity |
Cellular Component |
GO:0000118 histone deacetylase complex |
KEGG | - |
Reactome |
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer |
Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HDAC11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HDAC11 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HDAC11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HDAC11 in various data sets.
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Points in the above scatter plot represent the mutation difference of HDAC11 in various data sets.
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Summary | |
---|---|
Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HDAC11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HDAC11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HDAC11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HDAC11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HDAC11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HDAC11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HDAC11 |
Name | histone deacetylase 11 |
Aliases | HD11 |
Chromosomal Location | 3p25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HDAC11 collected from DrugBank database. |
Details on drugs targeting HDAC11.
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