Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF12203 Glutamine rich N terminal domain of histone deacetylase 4 PF00850 Histone deacetylase domain |
Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
Biological Process |
GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001975 response to amphetamine GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002521 leukocyte differentiation GO:0006476 protein deacetylation GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010830 regulation of myotube differentiation GO:0014075 response to amine GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0016202 regulation of striated muscle tissue development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030335 positive regulation of cell migration GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0040017 positive regulation of locomotion GO:0042113 B cell activation GO:0042692 muscle cell differentiation GO:0043434 response to peptide hormone GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0048634 regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048741 skeletal muscle fiber development GO:0048742 regulation of skeletal muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0098732 macromolecule deacylation GO:1901342 regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901861 regulation of muscle tissue development GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0070491 repressing transcription factor binding |
Cellular Component |
GO:0000118 histone deacetylase complex GO:0005667 transcription factor complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex |
KEGG | - |
Reactome |
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HDAC9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HDAC9 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HDAC9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HDAC9 in various data sets.
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Points in the above scatter plot represent the mutation difference of HDAC9 in various data sets.
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Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HDAC9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HDAC9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HDAC9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HDAC9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HDAC9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HDAC9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HDAC9 |
Name | histone deacetylase 9 |
Aliases | KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ...... |
Chromosomal Location | 7p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HDAC9 collected from DrugBank database. |
Details on drugs targeting HDAC9.
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