Summary | |
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Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00013 KH domain |
Function |
Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006869 lipid transport GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0010876 lipid localization GO:0016125 sterol metabolic process GO:1901615 organic hydroxy compound metabolic process GO:1902652 secondary alcohol metabolic process |
Molecular Function |
GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034364 high-density lipoprotein particle GO:1990777 lipoprotein particle |
KEGG | - |
Reactome |
R-HSA-194223: HDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HDLBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HDLBP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HDLBP in various data sets.
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Points in the above scatter plot represent the mutation difference of HDLBP in various data sets.
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Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HDLBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HDLBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HDLBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HDLBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HDLBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HDLBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HDLBP |
Name | high density lipoprotein binding protein |
Aliases | VGL; vigilin; PRO2900; HDL-binding protein; high density lipoprotein-binding protein |
Chromosomal Location | 2q37.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HDLBP collected from DrugBank database. |
There is no record. |