Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus |
Domain |
PF08146 BP28CT (NUC211) domain PF12397 U3 small nucleolar RNA-associated protein 10 |
Function |
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. |
Biological Process |
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006364 rRNA processing GO:0016072 rRNA metabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0030490 maturation of SSU-rRNA GO:0034470 ncRNA processing GO:0042254 ribosome biogenesis GO:0042274 ribosomal small subunit biogenesis GO:0045943 positive regulation of transcription from RNA polymerase I promoter |
Molecular Function |
GO:0030515 snoRNA binding |
Cellular Component |
GO:0030684 preribosome GO:0030686 90S preribosome GO:0032040 small-subunit processome GO:0034455 t-UTP complex GO:0044452 nucleolar part |
KEGG |
hsa03008 Ribosome biogenesis in eukaryotes |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6790901: rRNA modification in the nucleus and cytosol R-HSA-72312: rRNA processing R-HSA-8868773: rRNA processing in the nucleus and cytosol |
Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HEATR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HEATR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HEATR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HEATR1 in various data sets.
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Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HEATR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HEATR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HEATR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HEATR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HEATR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HEATR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HEATR1 |
Name | HEAT repeat containing 1 |
Aliases | FLJ10359; BAP28; UTP10; UTP10, small subunit (SSU) processome component, homolog (yeast); UTP10, small subun ...... |
Chromosomal Location | 1q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HEATR1 collected from DrugBank database. |
There is no record. |