Summary | |
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Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF07527 Hairy Orange PF00010 Helix-loop-helix DNA-binding domain |
Function |
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. |
Biological Process |
GO:0001655 urogenital system development GO:0001822 kidney development GO:0001837 epithelial to mesenchymal transition GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003177 pulmonary valve development GO:0003179 heart valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003184 pulmonary valve morphogenesis GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003231 cardiac ventricle development GO:0003272 endocardial cushion formation GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0007219 Notch signaling pathway GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0009755 hormone-mediated signaling pathway GO:0010469 regulation of receptor activity GO:0010720 positive regulation of cell development GO:0014031 mesenchymal cell development GO:0014706 striated muscle tissue development GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0032835 glomerulus development GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway GO:0035914 skeletal muscle cell differentiation GO:0043401 steroid hormone mediated signaling pathway GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045666 positive regulation of neuron differentiation GO:0048545 response to steroid hormone GO:0048762 mesenchymal cell differentiation GO:0050769 positive regulation of neurogenesis GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051962 positive regulation of nervous system development GO:0060317 cardiac epithelial to mesenchymal transition GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060765 regulation of androgen receptor signaling pathway GO:0060766 negative regulation of androgen receptor signaling pathway GO:0061326 renal tubule development GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072014 proximal tubule development GO:0072073 kidney epithelium development GO:0072080 nephron tubule development GO:0072132 mesenchyme morphogenesis GO:1905314 semi-lunar valve development GO:2000272 negative regulation of receptor activity GO:2000823 regulation of androgen receptor activity GO:2000824 negative regulation of androgen receptor activity |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003696 satellite DNA binding GO:0003714 transcription corepressor activity GO:0008134 transcription factor binding GO:0035939 microsatellite binding GO:0046982 protein heterodimerization activity GO:0050683 AF-1 domain binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer |
Summary | |
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Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HEYL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HEYL in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HEYL in various data sets.
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Points in the above scatter plot represent the mutation difference of HEYL in various data sets.
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Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HEYL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HEYL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HEYL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HEYL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HEYL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HEYL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HEYL |
Name | hes-related family bHLH transcription factor with YRPW motif-like |
Aliases | bHLHb33; HEY3; HESR3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related wit ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HEYL collected from DrugBank database. |
There is no record. |