Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lysosome membrane Multi-pass membrane protein Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain. |
Domain |
PF07786 Protein of unknown function (DUF1624) |
Function |
Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0030203 glycosaminoglycan metabolic process GO:0051259 protein oligomerization GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0008080 N-acetyltransferase activity GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups |
Cellular Component |
GO:0005765 lysosomal membrane GO:0098852 lytic vacuole membrane |
KEGG |
hsa04142 Lysosome hsa00531 Glycosaminoglycan degradation hsa01100 Metabolic pathways |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
---|---|
Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HGSNAT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HGSNAT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HGSNAT in various data sets.
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Points in the above scatter plot represent the mutation difference of HGSNAT in various data sets.
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Summary | |
---|---|
Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HGSNAT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HGSNAT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HGSNAT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HGSNAT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HGSNAT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HGSNAT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HGSNAT |
Name | heparan-alpha-glucosaminide N-acetyltransferase |
Aliases | FLJ32731; HGNAT; TMEM76; transmembrane protein 76; MPS3C |
Chromosomal Location | 8p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HGSNAT collected from DrugBank database. |
There is no record. |