Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization. |
Domain |
PF01230 HIT domain |
Function |
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. |
Biological Process |
GO:0006195 purine nucleotide catabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009154 purine ribonucleotide catabolic process GO:0009166 nucleotide catabolic process GO:0009261 ribonucleotide catabolic process GO:0019439 aromatic compound catabolic process GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0034655 nucleobase-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0050848 regulation of calcium-mediated signaling GO:0050850 positive regulation of calcium-mediated signaling GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072523 purine-containing compound catabolic process GO:0097193 intrinsic apoptotic signaling pathway GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0005080 protein kinase C binding |
Cellular Component |
GO:0000118 histone deacetylase complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HINT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HINT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HINT1 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HINT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HINT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HINT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HINT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HINT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HINT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HINT1 |
Name | histidine triad nucleotide binding protein 1 |
Aliases | PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HINT1 collected from DrugBank database. |
Details on drugs targeting HINT1.
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