Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=Mainly localizes in euchromatin. |
Domain |
PF00538 linker histone H1 and H5 family |
Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0007283 spermatogenesis GO:0031497 chromatin assembly GO:0034728 nucleosome organization GO:0048232 male gamete generation GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization |
Molecular Function |
GO:0003682 chromatin binding GO:0031490 chromatin DNA binding GO:0043566 structure-specific DNA binding |
Cellular Component |
GO:0000785 chromatin GO:0000786 nucleosome GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0005719 nuclear euchromatin GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0044815 DNA packaging complex |
KEGG | - |
Reactome |
R-HSA-211227: Activation of DNA fragmentation factor R-HSA-109581: Apoptosis R-HSA-140342: Apoptosis induced DNA fragmentation R-HSA-75153: Apoptotic execution phase R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-5357801: Programmed Cell Death |
Summary | |
---|---|
Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HIST1H1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HIST1H1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HIST1H1A in various data sets.
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Points in the above scatter plot represent the mutation difference of HIST1H1A in various data sets.
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Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIST1H1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIST1H1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIST1H1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIST1H1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HIST1H1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HIST1H1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HIST1H1A |
Name | histone cluster 1, H1a |
Aliases | H1.1; H1a; H1F1; H1 histone family, member 1; histone 1, H1a; Histone H1.1 |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HIST1H1A collected from DrugBank database. |
There is no record. |