Browse HIST1H2AI

Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Chromosome.
Domain PF00125 Core histone H2A/H2B/H3/H4
PF16211 C-terminus of histone H2A
Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

> Gene Ontology
 
Biological Process GO:0006342 chromatin silencing
GO:0016458 gene silencing
GO:0040029 regulation of gene expression, epigenetic
GO:0045814 negative regulation of gene expression, epigenetic
Molecular Function GO:0046982 protein heterodimerization activity
Cellular Component GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0032993 protein-DNA complex
GO:0044454 nuclear chromosome part
GO:0044815 DNA packaging complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HIST1H2AI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HIST1H2AI in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.63 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HIST1H2AI in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.130.184
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7170.719
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.6650.549
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0580.261
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.160.346
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7327.02e-05
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIST1H2AI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIST1H2AI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIST1H2AI.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIST1H2AI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HIST1H2AI expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HIST1H2AI and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHIST1H2AI
Namehistone cluster 1, H2ai
Aliases H2A/c; H2AFC; H2A histone family, member C; histone 1, H2ai
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HIST1H2AI collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.