Browse HIVEP1

Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm Nucleus
Domain -
Function

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

> Gene Ontology
 
Biological Process -
Molecular Function GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0035326 enhancer binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HIVEP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HIVEP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.57 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HIVEP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1310.542
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2950.685
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0070.991
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3970.308
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8720.712
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2080.947
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3710.224
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4470.744
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2910.849
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6940.447
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.7230.157
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0480.58
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HIVEP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.16.84.30.673
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211733.311.821.50.148
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131138.518.220.30.386
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.57.43.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIVEP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIVEP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIVEP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIVEP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HIVEP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HIVEP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHIVEP1
Namehuman immunodeficiency virus type I enhancer binding protein 1
Aliases CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ......
Chromosomal Location6p24-p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HIVEP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.