Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm Nucleus |
Domain | - |
Function |
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
Biological Process | - |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0035326 enhancer binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HIVEP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HIVEP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HIVEP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HIVEP1 in various data sets.
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Summary | |
---|---|
Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIVEP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIVEP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIVEP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIVEP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HIVEP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HIVEP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HIVEP1 |
Name | human immunodeficiency virus type I enhancer binding protein 1 |
Aliases | CIRIP; CRYBP1; PRDII-BF1; ZAS1; Schnurri-1; ZNF40A; ZNF40; human immunodeficiency virus type I enhancer-bind ...... |
Chromosomal Location | 6p24-p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HIVEP1 collected from DrugBank database. |
There is no record. |