Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. |
Domain |
PF12347 Holliday junction regulator protein family C-terminal repeat PF12346 Holliday junction recognition protein-associated repeat PF10384 Centromere protein Scm3 |
Function |
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0007059 chromosome segregation GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043254 regulation of protein complex assembly GO:0043486 histone exchange GO:0051098 regulation of binding GO:0051101 regulation of DNA binding GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization |
Molecular Function |
GO:0042393 histone binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-73886: Chromosome Maintenance R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-774815: Nucleosome assembly |
Summary | |
---|---|
Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HJURP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HJURP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HJURP in various data sets.
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Points in the above scatter plot represent the mutation difference of HJURP in various data sets.
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Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HJURP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HJURP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HJURP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HJURP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HJURP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HJURP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HJURP |
Name | Holliday junction recognition protein |
Aliases | DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HJURP collected from DrugBank database. |
There is no record. |