Browse HJURP

Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Domain PF12347 Holliday junction regulator protein family C-terminal repeat
PF12346 Holliday junction recognition protein-associated repeat
PF10384 Centromere protein Scm3
Function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

> Gene Ontology
 
Biological Process GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0031055 chromatin remodeling at centromere
GO:0031497 chromatin assembly
GO:0034080 CENP-A containing nucleosome assembly
GO:0034508 centromere complex assembly
GO:0034724 DNA replication-independent nucleosome organization
GO:0034728 nucleosome organization
GO:0043044 ATP-dependent chromatin remodeling
GO:0043254 regulation of protein complex assembly
GO:0043486 histone exchange
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0061641 CENP-A containing chromatin organization
GO:0065004 protein-DNA complex assembly
GO:0071103 DNA conformation change
GO:0071824 protein-DNA complex subunit organization
Molecular Function GO:0042393 histone binding
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000779 condensed chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-73886: Chromosome Maintenance
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-774815: Nucleosome assembly
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HJURP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HJURP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HJURP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6320.0446
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3480.8
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8450.44
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4730.307
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1680.9
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8680.647
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0180.963
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5480.669
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7160.563
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2630.748
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5540.594
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5060.000126
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HJURP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HJURP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HJURP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HJURP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HJURP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HJURP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HJURP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHJURP
NameHolliday junction recognition protein
Aliases DKFZp762E1312; URLC9; hFLEG1; FAKTS; 14-3-3-associated AKT substrate; fetal liver expressing gene 1; fetal l ......
Chromosomal Location2q37.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HJURP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.