Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 3: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 4: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 5: Secreted ; SUBCELLULAR LOCATION: Isoform 6: Secreted ; SUBCELLULAR LOCATION: Isoform 7: Secreted |
Domain |
PF07654 Immunoglobulin C1-set domain PF00129 Class I Histocompatibility antigen |
Function |
Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002507 tolerance induction GO:0002517 T cell tolerance induction GO:0002521 leukocyte differentiation GO:0002643 regulation of tolerance induction GO:0002645 positive regulation of tolerance induction GO:0002664 regulation of T cell tolerance induction GO:0002666 positive regulation of T cell tolerance induction GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002764 immune response-regulating signaling pathway GO:0002765 immune response-inhibiting signal transduction GO:0002767 immune response-inhibiting cell surface receptor signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006968 cellular defense response GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0032615 interleukin-12 production GO:0032655 regulation of interleukin-12 production GO:0032735 positive regulation of interleukin-12 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0045066 regulatory T cell differentiation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045589 regulation of regulatory T cell differentiation GO:0045591 positive regulation of regulatory T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0046651 lymphocyte proliferation GO:0048002 antigen processing and presentation of peptide antigen GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050777 negative regulation of immune response GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060333 interferon-gamma-mediated signaling pathway GO:0060337 type I interferon signaling pathway GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0071593 lymphocyte aggregation GO:0097028 dendritic cell differentiation GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2001198 regulation of dendritic cell differentiation GO:2001199 negative regulation of dendritic cell differentiation |
Molecular Function |
GO:0003823 antigen binding |
Cellular Component |
GO:0005769 early endosome GO:0010008 endosome membrane GO:0012507 ER to Golgi transport vesicle membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030139 endocytic vesicle GO:0030176 integral component of endoplasmic reticulum membrane GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0031901 early endosome membrane GO:0042611 MHC protein complex GO:0042612 MHC class I protein complex GO:0044440 endosomal part GO:0045335 phagocytic vesicle GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane GO:0098552 side of membrane GO:0098553 lumenal side of endoplasmic reticulum membrane |
KEGG |
hsa04144 Endocytosis hsa04145 Phagosome hsa04514 Cell adhesion molecules (CAMs) hsa04612 Antigen processing and presentation hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983170: Antigen Presentation R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1236974: ER-Phagosome pathway R-HSA-1236977: Endosomal/Vacuolar pathway R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-877300: Interferon gamma signaling |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HLA-G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HLA-G and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HLA-G in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HLA-G in various data sets.
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Points in the above scatter plot represent the mutation difference of HLA-G in various data sets.
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Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HLA-G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HLA-G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HLA-G. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HLA-G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HLA-G expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HLA-G and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HLA-G |
Name | major histocompatibility complex, class I, G |
Aliases | b2 microglobulin; HLA-G histocompatibility antigen, class I, G; MHC-G; HLA G antigen; MHC class I antigen G; ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HLA-G collected from DrugBank database. |
There is no record. |