Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF02178 AT hook motif |
Function |
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000086 G2/M transition of mitotic cell cycle GO:0000726 non-recombinational repair GO:0001501 skeletal system development GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0001707 mesoderm formation GO:0001837 epithelial to mesenchymal transition GO:0002062 chondrocyte differentiation GO:0003131 mesodermal-endodermal cell signaling GO:0006282 regulation of DNA repair GO:0006284 base-excision repair GO:0006302 double-strand break repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006338 chromatin remodeling GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007093 mitotic cell cycle checkpoint GO:0007095 mitotic G2 DNA damage checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007369 gastrulation GO:0007492 endoderm development GO:0007498 mesoderm development GO:0007568 aging GO:0007569 cell aging GO:0009314 response to radiation GO:0009615 response to virus GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010948 negative regulation of cell cycle process GO:0010972 negative regulation of G2/M transition of mitotic cell cycle GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019080 viral gene expression GO:0019083 viral transcription GO:0019827 stem cell population maintenance GO:0030261 chromosome condensation GO:0031049 programmed DNA elimination GO:0031052 chromosome breakage GO:0031497 chromatin assembly GO:0031507 heterochromatin assembly GO:0031570 DNA integrity checkpoint GO:0031572 G2 DNA damage checkpoint GO:0032897 negative regulation of viral transcription GO:0035404 histone-serine phosphorylation GO:0035690 cellular response to drug GO:0035821 modification of morphology or physiology of other organism GO:0035978 histone H2A-S139 phosphorylation GO:0035986 senescence-associated heterochromatin focus assembly GO:0035987 endodermal cell differentiation GO:0035988 chondrocyte proliferation GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate GO:0039694 viral RNA genome replication GO:0039703 RNA replication GO:0042493 response to drug GO:0042769 DNA damage response, detection of DNA damage GO:0043388 positive regulation of DNA binding GO:0043392 negative regulation of DNA binding GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043922 negative regulation by host of viral transcription GO:0044033 multi-organism metabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044818 mitotic G2/M transition checkpoint GO:0044839 cell cycle G2/M phase transition GO:0045069 regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045444 fat cell differentiation GO:0045738 negative regulation of DNA repair GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045930 negative regulation of mitotic cell cycle GO:0046782 regulation of viral transcription GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048525 negative regulation of viral process GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0050792 regulation of viral process GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051216 cartilage development GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0060485 mesenchyme development GO:0061448 connective tissue development GO:0070828 heterochromatin organization GO:0071103 DNA conformation change GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071481 cellular response to X-ray GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0090068 positive regulation of cell cycle process GO:0090342 regulation of cell aging GO:0090343 positive regulation of cell aging GO:0090398 cellular senescence GO:0090402 oncogene-induced cell senescence GO:0098727 maintenance of cell number GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902749 regulation of cell cycle G2/M phase transition GO:1902750 negative regulation of cell cycle G2/M phase transition GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1990164 histone H2A phosphorylation GO:2000036 regulation of stem cell population maintenance GO:2000648 positive regulation of stem cell proliferation GO:2000677 regulation of transcription regulatory region DNA binding GO:2000679 positive regulation of transcription regulatory region DNA binding GO:2000683 regulation of cellular response to X-ray GO:2000685 positive regulation of cellular response to X-ray GO:2000772 regulation of cellular senescence GO:2000774 positive regulation of cellular senescence GO:2000779 regulation of double-strand break repair GO:2000780 negative regulation of double-strand break repair GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001023 regulation of response to drug GO:2001032 regulation of double-strand break repair via nonhomologous end joining GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining GO:2001038 regulation of cellular response to drug |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003680 AT DNA binding GO:0003682 chromatin binding GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0004520 endodeoxyribonuclease activity GO:0004536 deoxyribonuclease activity GO:0004674 protein serine/threonine kinase activity GO:0004677 DNA-dependent protein kinase activity GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035497 cAMP response element binding GO:0035500 MH2 domain binding GO:0035501 MH1 domain binding GO:0043566 structure-specific DNA binding GO:0046332 SMAD binding GO:0051575 5'-deoxyribose-5-phosphate lyase activity GO:0070742 C2H2 zinc finger domain binding |
Cellular Component |
GO:0000785 chromatin GO:0000792 heterochromatin GO:0032993 protein-DNA complex GO:0035985 senescence-associated heterochromatin focus GO:0071141 SMAD protein complex |
KEGG | - |
Reactome |
R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HMGA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HMGA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HMGA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of HMGA2 in various data sets.
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Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HMGA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HMGA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HMGA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HMGA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HMGA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HMGA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HMGA2 |
Name | high mobility group AT-hook 2 |
Aliases | BABL; LIPO; HMGIC; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGI-C; STQTL9; High-mo ...... |
Chromosomal Location | 12q15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HMGA2 collected from DrugBank database. |
There is no record. |