Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell surface Cytoplasm |
Domain |
PF15908 Hyaluronan mediated motility receptor C-terminal PF15905 Hyaluronan mediated motility receptor N-terminal |
Function |
Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030214 hyaluronan catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0005539 glycosaminoglycan binding GO:0005540 hyaluronic acid binding |
Cellular Component | - |
KEGG |
hsa04512 ECM-receptor interaction |
Reactome |
R-HSA-8854518: AURKA Activation by TPX2 R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69275: G2/M Transition R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2142845: Hyaluronan metabolism R-HSA-2160916: Hyaluronan uptake and degradation R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-453274: Mitotic G2-G2/M phases |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HMMR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HMMR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HMMR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HMMR in various data sets.
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Points in the above scatter plot represent the mutation difference of HMMR in various data sets.
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Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HMMR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HMMR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HMMR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HMMR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HMMR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HMMR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HMMR |
Name | hyaluronan-mediated motility receptor (RHAMM) |
Aliases | RHAMM; CD168; IHABP; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motilit ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HMMR collected from DrugBank database. |
Details on drugs targeting HMMR.
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