Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm. |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM PF08080 RNPHF zinc finger |
Function |
Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0008543 fibroblast growth factor receptor signaling pathway GO:0043484 regulation of RNA splicing GO:0044344 cellular response to fibroblast growth factor stimulus GO:0071774 response to fibroblast growth factor |
Molecular Function |
GO:0003727 single-stranded RNA binding GO:0008134 transcription factor binding GO:0017025 TBP-class protein binding |
Cellular Component |
GO:0005681 spliceosomal complex GO:0071013 catalytic step 2 spliceosome |
KEGG | - |
Reactome |
R-HSA-6803529: FGFR2 alternative splicing R-HSA-74160: Gene Expression R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-162582: Signal Transduction R-HSA-190236: Signaling by FGFR R-HSA-5654738: Signaling by FGFR2 R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HNRNPF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HNRNPF in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HNRNPF in various data sets.
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Points in the above scatter plot represent the mutation difference of HNRNPF in various data sets.
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Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HNRNPF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HNRNPF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HNRNPF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HNRNPF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HNRNPF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HNRNPF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HNRNPF |
Name | heterogeneous nuclear ribonucleoprotein F |
Aliases | HNRPF; OK/SW-cl.23; mcs94-1; HnRNP F protein; nucleolin-like protein mcs94-1; hnRNP F |
Chromosomal Location | 10q11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HNRNPF collected from DrugBank database. |
Details on drugs targeting HNRNPF.
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