Browse HORMAD1

Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity).
Domain PF02301 HORMA domain
Function

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000819 sister chromatid segregation
GO:0001701 in utero embryonic development
GO:0001824 blastocyst development
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007129 synapsis
GO:0007130 synaptonemal complex assembly
GO:0007135 meiosis II
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0010639 negative regulation of organelle organization
GO:0010948 negative regulation of cell cycle process
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0033313 meiotic cell cycle checkpoint
GO:0040020 regulation of meiotic nuclear division
GO:0042138 meiotic DNA double-strand break formation
GO:0045132 meiotic chromosome segregation
GO:0045143 homologous chromosome segregation
GO:0045144 meiotic sister chromatid segregation
GO:0045786 negative regulation of cell cycle
GO:0045835 negative regulation of meiotic nuclear division
GO:0048232 male gamete generation
GO:0048477 oogenesis
GO:0051177 meiotic sister chromatid cohesion
GO:0051321 meiotic cell cycle
GO:0051445 regulation of meiotic cell cycle
GO:0051447 negative regulation of meiotic cell cycle
GO:0051598 meiotic recombination checkpoint
GO:0051783 regulation of nuclear division
GO:0051784 negative regulation of nuclear division
GO:0051983 regulation of chromosome segregation
GO:0060629 regulation of homologous chromosome segregation
GO:0060631 regulation of meiosis I
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0070193 synaptonemal complex organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0098813 nuclear chromosome segregation
GO:1903046 meiotic cell cycle process
GO:2000241 regulation of reproductive process
GO:2000242 negative regulation of reproductive process
Molecular Function -
Cellular Component GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HORMAD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HORMAD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HORMAD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1980.733
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1130.905
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4480.55
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0240.968
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4140.703
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5730.665
729033130MelanomaallAnti-PD-1 (nivolumab) 26232.1360.0254
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.3180.0877
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11122.1590.136
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4470.362
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4470.529
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0490.894
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HORMAD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HORMAD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HORMAD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HORMAD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HORMAD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HORMAD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HORMAD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHORMAD1
NameHORMA domain containing 1
Aliases DKFZP434A1315; CT46; cancer/testis antigen 46; NOHMA; newborn ovary HORMA protein; HORMA domain-containing p ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HORMAD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.