Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00046 Homeobox domain |
Function |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. |
Biological Process |
GO:0001501 skeletal system development GO:0007423 sensory organ development GO:0007605 sensory perception of sound GO:0007632 visual behavior GO:0007634 optokinetic behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0021545 cranial nerve development GO:0021560 abducens nerve development GO:0021598 abducens nerve morphogenesis GO:0021599 abducens nerve formation GO:0021602 cranial nerve morphogenesis GO:0021603 cranial nerve formation GO:0021675 nerve development GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042473 outer ear morphogenesis GO:0043583 ear development GO:0044708 single-organism behavior GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048701 embryonic cranial skeleton morphogenesis GO:0048702 embryonic neurocranium morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048752 semicircular canal morphogenesis GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0050795 regulation of behavior GO:0050890 cognition GO:0050905 neuromuscular process GO:0050954 sensory perception of mechanical stimulus GO:0060840 artery development GO:0060872 semicircular canal development GO:0060876 semicircular canal formation GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090596 sensory organ morphogenesis GO:1904888 cranial skeletal system development |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1266738: Developmental Biology |
Summary | |
---|---|
Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HOXA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between HOXA1 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HOXA1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HOXA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HOXA1 in various data sets.
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Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HOXA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HOXA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HOXA1 |
Name | homeobox A1 |
Aliases | HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HOXA1 collected from DrugBank database. |
There is no record. |