Browse HOXA1

Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00046 Homeobox domain
Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0007423 sensory organ development
GO:0007605 sensory perception of sound
GO:0007632 visual behavior
GO:0007634 optokinetic behavior
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0021545 cranial nerve development
GO:0021560 abducens nerve development
GO:0021598 abducens nerve morphogenesis
GO:0021599 abducens nerve formation
GO:0021602 cranial nerve morphogenesis
GO:0021603 cranial nerve formation
GO:0021675 nerve development
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0043583 ear development
GO:0044708 single-organism behavior
GO:0048514 blood vessel morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048702 embryonic neurocranium morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048752 semicircular canal morphogenesis
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0050795 regulation of behavior
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0050954 sensory perception of mechanical stimulus
GO:0060840 artery development
GO:0060872 semicircular canal development
GO:0060876 semicircular canal formation
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090596 sensory organ morphogenesis
GO:1904888 cranial skeletal system development
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1266738: Developmental Biology
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOXA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HOXA1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29662483lung adenocarcinomaPromote immunityHOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA that has been shown to be a key regulator of myeloid cell development by targeting HOXA1.
22962263Lung Carcinoma; MelanomaPromote immunityA comprehensive approach using transcriptome analysis, argonaute protein immunoprecipitation, and luciferase reporter assay revealed that the genes PTPN1, HOXA1, and TP53I11 were miR-210 target genes regulated in hypoxic cells. In support of their primary importance in mediating the immunosuppressive effects of miR-210, coordinate silencing of PTPN1, HOXA1, and TP53I11 dramatically decreased tumor cell susceptibility to CTL-mediated lysis.
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOXA1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOXA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0730.815
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2740.722
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.070.901
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4140.234
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3560.701
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4920.677
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0330.954
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7080.424
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9820.24
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5720.378
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6490.464
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0260.876
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HOXA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOXA1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOXA1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOXA1
Namehomeobox A1
Aliases HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOXA1 collected from DrugBank database.
> Drugs from DrugBank database
 

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