Summary | |
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Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00046 Homeobox domain PF12284 Hox protein A13 N terminal |
Function |
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
Biological Process |
GO:0001501 skeletal system development GO:0007442 hindgut morphogenesis GO:0035239 tube morphogenesis GO:0048546 digestive tract morphogenesis GO:0048565 digestive tract development GO:0048619 embryonic hindgut morphogenesis GO:0055123 digestive system development GO:0061525 hindgut development |
Molecular Function | - |
Cellular Component |
GO:0045111 intermediate filament cytoskeleton |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HOXA13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HOXA13 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HOXA13 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA13. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HOXA13 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HOXA13 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HOXA13 |
Name | homeobox A13 |
Aliases | HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ...... |
Chromosomal Location | 7p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HOXA13 collected from DrugBank database. |
There is no record. |