Browse HOXB2

Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00046 Homeobox domain
Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0002011 morphogenesis of an epithelial sheet
GO:0003002 regionalization
GO:0003013 circulatory system process
GO:0007389 pattern specification process
GO:0008015 blood circulation
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021545 cranial nerve development
GO:0021546 rhombomere development
GO:0021561 facial nerve development
GO:0021569 rhombomere 3 development
GO:0021570 rhombomere 4 development
GO:0021602 cranial nerve morphogenesis
GO:0021604 cranial nerve structural organization
GO:0021610 facial nerve morphogenesis
GO:0021612 facial nerve structural organization
GO:0021675 nerve development
GO:0021783 preganglionic parasympathetic fiber development
GO:0030902 hindbrain development
GO:0048483 autonomic nervous system development
GO:0048486 parasympathetic nervous system development
GO:0048532 anatomical structure arrangement
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048857 neural nucleus development
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1266738: Developmental Biology
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOXB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOXB2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOXB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.1240.0351
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3520.47
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.9530.482
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5750.178
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6990.651
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.420.831
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6740.244
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5920.608
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6060.581
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0210.983
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2810.838
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4080.0462
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HOXB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275905.1-5.10.549
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXB2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOXB2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOXB2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOXB2
Namehomeobox B2
Aliases HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOXB2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.