Summary | |
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Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00046 Homeobox domain |
Function |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
Biological Process |
GO:0001501 skeletal system development GO:0002011 morphogenesis of an epithelial sheet GO:0003002 regionalization GO:0003013 circulatory system process GO:0007389 pattern specification process GO:0008015 blood circulation GO:0009952 anterior/posterior pattern specification GO:0009953 dorsal/ventral pattern formation GO:0021545 cranial nerve development GO:0021546 rhombomere development GO:0021561 facial nerve development GO:0021569 rhombomere 3 development GO:0021570 rhombomere 4 development GO:0021602 cranial nerve morphogenesis GO:0021604 cranial nerve structural organization GO:0021610 facial nerve morphogenesis GO:0021612 facial nerve structural organization GO:0021675 nerve development GO:0021783 preganglionic parasympathetic fiber development GO:0030902 hindbrain development GO:0048483 autonomic nervous system development GO:0048486 parasympathetic nervous system development GO:0048532 anatomical structure arrangement GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048857 neural nucleus development |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1266738: Developmental Biology |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HOXB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HOXB2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HOXB2 in various data sets.
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Points in the above scatter plot represent the mutation difference of HOXB2 in various data sets.
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Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXB2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HOXB2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HOXB2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HOXB2 |
Name | homeobox B2 |
Aliases | HOX2H; homeo box B2; Hox-2.8; K8 home protein; homeo box 2H; homeobox protein Hox-2.8; homeobox protein Hox- ...... |
Chromosomal Location | 17q21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HOXB2 collected from DrugBank database. |
There is no record. |