Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF12045 Protein of unknown function (DUF3528) PF00046 Homeobox domain |
Function |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. |
Biological Process |
GO:0001501 skeletal system development GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001759 organ induction GO:0001822 kidney development GO:0003002 regionalization GO:0003156 regulation of animal organ formation GO:0007389 pattern specification process GO:0007492 endoderm development GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0010092 specification of animal organ identity GO:0030326 embryonic limb morphogenesis GO:0031128 developmental induction GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0042733 embryonic digit morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048645 animal organ formation GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0060173 limb development GO:0060272 embryonic skeletal joint morphogenesis GO:0072001 renal system development GO:0072498 embryonic skeletal joint development GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HOXC11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HOXC11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HOXC11 in various data sets.
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Points in the above scatter plot represent the mutation difference of HOXC11 in various data sets.
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Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXC11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXC11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXC11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXC11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HOXC11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HOXC11 |
Name | homeobox C11 |
Aliases | HOX3H; homeo box C11; homeobox protein Hox-3H; Homeobox protein Hox-C11 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HOXC11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |