Summary | |
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Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00089 Trypsin |
Function |
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. ; FUNCTION: Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0002526 acute inflammatory response GO:0006898 receptor-mediated endocytosis GO:0006953 acute-phase response GO:0006979 response to oxidative stress GO:0009636 response to toxic substance GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010035 response to inorganic substance GO:0010310 regulation of hydrogen peroxide metabolic process GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0042542 response to hydrogen peroxide GO:0042742 defense response to bacterium GO:0042743 hydrogen peroxide metabolic process GO:0042744 hydrogen peroxide catabolic process GO:0051341 regulation of oxidoreductase activity GO:0051354 negative regulation of oxidoreductase activity GO:0072593 reactive oxygen species metabolic process GO:0098542 defense response to other organism GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification GO:2000295 regulation of hydrogen peroxide catabolic process GO:2000296 negative regulation of hydrogen peroxide catabolic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process |
Molecular Function |
GO:0016209 antioxidant activity GO:0030492 hemoglobin binding |
Cellular Component |
GO:0030139 endocytic vesicle GO:0031838 haptoglobin-hemoglobin complex GO:0031983 vesicle lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0071682 endocytic vesicle lumen GO:0072562 blood microparticle |
KEGG | - |
Reactome |
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-2168880: Scavenging of heme from plasma R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HP in various data sets.
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Points in the above scatter plot represent the mutation difference of HP in various data sets.
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Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HP |
Name | haptoglobin |
Aliases | BP2ALPHA2; HPA1S; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alp ...... |
Chromosomal Location | 16q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HP collected from DrugBank database. |
There is no record. |