Browse HPGDS

Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF14497 Glutathione S-transferase
PF02798 Glutathione S-transferase
Function

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

> Gene Ontology
 
Biological Process GO:0001516 prostaglandin biosynthetic process
GO:0001676 long-chain fatty acid metabolic process
GO:0002176 male germ cell proliferation
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0006692 prostanoid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006790 sulfur compound metabolic process
GO:0007626 locomotory behavior
GO:0016053 organic acid biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0033559 unsaturated fatty acid metabolic process
GO:0036093 germ cell proliferation
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0044272 sulfur compound biosynthetic process
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046456 icosanoid biosynthetic process
GO:0046457 prostanoid biosynthetic process
GO:0072330 monocarboxylic acid biosynthetic process
GO:1901685 glutathione derivative metabolic process
GO:1901687 glutathione derivative biosynthetic process
GO:2000241 regulation of reproductive process
GO:2000242 negative regulation of reproductive process
GO:2000254 regulation of male germ cell proliferation
GO:2000255 negative regulation of male germ cell proliferation
Molecular Function GO:0000287 magnesium ion binding
GO:0004364 glutathione transferase activity
GO:0004667 prostaglandin-D synthase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016853 isomerase activity
GO:0016860 intramolecular oxidoreductase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00480 Glutathione metabolism
hsa00590 Arachidonic acid metabolism
hsa00980 Metabolism of xenobiotics by cytochrome P450
hsa00982 Drug metabolism - cytochrome P450
hsa01100 Metabolic pathways
Reactome R-HSA-2142753: Arachidonic acid metabolism
R-HSA-211859: Biological oxidations
R-HSA-156590: Glutathione conjugation
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-156580: Phase II conjugation
R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HPGDS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HPGDS in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HPGDS in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1090.743
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1870.754
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0490.92
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2810.555
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3370.739
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2260.818
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.9660.0371
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.220.107
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7590.368
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9690.353
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9710.146
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6280.000396
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HPGDS in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HPGDS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HPGDS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HPGDS.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HPGDS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HPGDS expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HPGDS and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHPGDS
Namehematopoietic prostaglandin D synthase
Aliases GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location4q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HPGDS collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HPGDS.
ID Name Drug Type Targets #Targets
DB00143GlutathioneSmall MoleculeAKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......41
DB00162Vitamin ASmall MoleculeALDH1A1, ALDH1A2, ALDH1A3, APOD, DHRS3, DHRS4, HPGDS, LRAT, RBP1, ......18
DB00755TretinoinSmall MoleculeALDH1A1, ALDH1A2, CYP26A1, CYP26B1, CYP26C1, GPRC5A, HPGDS, LCN1, ......19
DB018972-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium ChlorideSmall MoleculeHPGDS1
DB076133-phenyl-5-(1H-pyrazol-3-yl)isoxazoleSmall MoleculeHPGDS1
DB07614PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLESmall MoleculeHPGDS1
DB07615TranilastSmall MoleculeHPGDS1
DB076164-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acidSmall MoleculeHPGDS1
DB079174-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINESmall MoleculeHPGDS1
DB08313nocodazoleSmall MoleculeHPGDS1
DB086953-(4-nitrophenyl)-1H-pyrazoleSmall MoleculeHPGDS1
DB087901-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACIDSmall MoleculeHPGDS1
DB09462GlycerinSmall MoleculeADH1B, ARF1, GSTP1, HPGDS, ISYNA1, ITPR1, NAGA, PAEP, PAPSS1, PLA2 ......13