Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF14497 Glutathione S-transferase PF02798 Glutathione S-transferase |
Function |
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. |
Biological Process |
GO:0001516 prostaglandin biosynthetic process GO:0001676 long-chain fatty acid metabolic process GO:0002176 male germ cell proliferation GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0006790 sulfur compound metabolic process GO:0007626 locomotory behavior GO:0016053 organic acid biosynthetic process GO:0019369 arachidonic acid metabolic process GO:0019371 cyclooxygenase pathway GO:0033559 unsaturated fatty acid metabolic process GO:0036093 germ cell proliferation GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0044272 sulfur compound biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901685 glutathione derivative metabolic process GO:1901687 glutathione derivative biosynthetic process GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2000254 regulation of male germ cell proliferation GO:2000255 negative regulation of male germ cell proliferation |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004364 glutathione transferase activity GO:0004667 prostaglandin-D synthase activity GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity |
Cellular Component | - |
KEGG |
hsa00480 Glutathione metabolism hsa00590 Arachidonic acid metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 hsa01100 Metabolic pathways |
Reactome |
R-HSA-2142753: Arachidonic acid metabolism R-HSA-211859: Biological oxidations R-HSA-156590: Glutathione conjugation R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-156580: Phase II conjugation R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HPGDS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of HPGDS in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HPGDS in various data sets.
|
Points in the above scatter plot represent the mutation difference of HPGDS in various data sets.
|
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HPGDS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HPGDS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HPGDS. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HPGDS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HPGDS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HPGDS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HPGDS |
Name | hematopoietic prostaglandin D synthase |
Aliases | GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ...... |
Chromosomal Location | 4q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HPGDS collected from DrugBank database. |
Details on drugs targeting HPGDS.
|