Summary | |
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Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. |
Biological Process |
GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006066 alcohol metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007611 learning or memory GO:0007612 learning GO:0007613 memory GO:0007632 visual behavior GO:0008015 blood circulation GO:0008306 associative learning GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010919 regulation of inositol phosphate biosynthetic process GO:0016051 carbohydrate biosynthetic process GO:0019229 regulation of vasoconstriction GO:0019751 polyol metabolic process GO:0019932 second-messenger-mediated signaling GO:0030595 leukocyte chemotaxis GO:0032957 inositol trisphosphate metabolic process GO:0032958 inositol phosphate biosynthetic process GO:0032959 inositol trisphosphate biosynthetic process GO:0032960 regulation of inositol trisphosphate biosynthetic process GO:0032962 positive regulation of inositol trisphosphate biosynthetic process GO:0034776 response to histamine GO:0035150 regulation of tube size GO:0042310 vasoconstriction GO:0043114 regulation of vascular permeability GO:0043255 regulation of carbohydrate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0044057 regulation of system process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044708 single-organism behavior GO:0044723 single-organism carbohydrate metabolic process GO:0045907 positive regulation of vasoconstriction GO:0045913 positive regulation of carbohydrate metabolic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0048016 inositol phosphate-mediated signaling GO:0048167 regulation of synaptic plasticity GO:0048245 eosinophil chemotaxis GO:0050804 modulation of synaptic transmission GO:0050880 regulation of blood vessel size GO:0050890 cognition GO:0050900 leukocyte migration GO:0060326 cell chemotaxis GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071420 cellular response to histamine GO:0071621 granulocyte chemotaxis GO:0072677 eosinophil migration GO:0090066 regulation of anatomical structure size GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation |
Molecular Function |
GO:0004969 histamine receptor activity GO:0008227 G-protein coupled amine receptor activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04750 Inflammatory mediator regulation of TRP channels |
Reactome |
R-HSA-375280: Amine ligand-binding receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-390650: Histamine receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HRH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HRH1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HRH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HRH1 in various data sets.
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Summary | |
---|---|
Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HRH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HRH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HRH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HRH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HRH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HRH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HRH1 |
Name | histamine receptor H1 |
Aliases | H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor |
Chromosomal Location | 3p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HRH1 collected from DrugBank database. |
Details on drugs targeting HRH1.
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