Summary | |
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Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF00685 Sulfotransferase domain |
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0030203 glycosaminoglycan metabolic process |
Molecular Function |
GO:0008146 sulfotransferase activity GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0016782 transferase activity, transferring sulfur-containing groups GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity GO:0034483 heparan sulfate sulfotransferase activity |
Cellular Component | - |
KEGG |
hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
Reactome |
R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022928: HS-GAG biosynthesis R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HS3ST3A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HS3ST3A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HS3ST3A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HS3ST3A1 in various data sets.
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Summary | |
---|---|
Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HS3ST3A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HS3ST3A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HS3ST3A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HS3ST3A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HS3ST3A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HS3ST3A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | HS3ST3A1 |
Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
Aliases | 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ...... |
Chromosomal Location | 17p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HS3ST3A1 collected from DrugBank database. |
Details on drugs targeting HS3ST3A1.
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