Browse HS3ST3A1

Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Single-pass type II membrane protein
Domain PF00685 Sulfotransferase domain
Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

> Gene Ontology
 
Biological Process GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
Molecular Function GO:0008146 sulfotransferase activity
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO:0016782 transferase activity, transferring sulfur-containing groups
GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
GO:0034483 heparan sulfate sulfotransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Reactome R-HSA-1630316: Glycosaminoglycan metabolism
R-HSA-2022928: HS-GAG biosynthesis
R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HS3ST3A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HS3ST3A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HS3ST3A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0750.0507
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0110.309
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.120.166
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.0680.0684
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6440.595
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.5930.325
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6150.387
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.7150.494
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5310.632
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.7070.00503
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6730.0427
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1090.687
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HS3ST3A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916018.8-18.80.28
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47028.6-28.60.491
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HS3ST3A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HS3ST3A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HS3ST3A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HS3ST3A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HS3ST3A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HS3ST3A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHS3ST3A1
Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Aliases 3OST3A1; 30ST3A1; 3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sul ......
Chromosomal Location17p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HS3ST3A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HS3ST3A1.
ID Name Drug Type Targets #Targets
DB01812Adenosine-3'-5'-DiphosphateSmall MoleculeHS3ST1, HS3ST3A1, NDST1, RNASE1, RNASE2, SULT1A1, SULT1B1, SULT1E1 ......10
DB02264O2-Sulfo-Glucuronic AcidSmall MoleculeFGF1, HGF, HS3ST3A13
DB03959N,O6-Disulfo-GlucosamineSmall MoleculeANXA5, FGF1, FGF2, HGF, HS3ST3A15
DB039811,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic AcidSmall MoleculeANXA5, FGF2, HS3ST3A13
DB04272Citric AcidSmall MoleculeAKR1B1, ANG, APRT, BHMT, C8G, CPB1, CS, CTDSP1, GNMT, HGS, HS3ST3A ......23